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Polyethylene glycol combined with lactulose has better efficacy than polyethylene glycol alone in bowel preparation before colonoscopy: A meta-analysis
Zhang, Xiaofen; Chen, Yishu; Chen, Ye; Zhu, Wei; Tang, Chenxi; Lamm, Shelby; Li, Lan.
Afiliação
  • Zhang, Xiaofen; Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Gastroenterology. Zhejiang Province. CN
  • Chen, Yishu; Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Gastroenterology. Zhejiang Province. CN
  • Chen, Ye; Northern Arizona University. Department of Mathematics and Statistics. Flagstaff. US
  • Zhu, Wei; Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Gastroenterology. Zhejiang Province. CN
  • Tang, Chenxi; Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Gastroenterology. Zhejiang Province. CN
  • Lamm, Shelby; Northern Arizona University. Department of Mathematics and Statistics. Flagstaff. US
  • Li, Lan; Zhejiang University School of Medicine. The First Affiliated Hospital. Department of Gastroenterology. Zhejiang Province. CN
Clinics ; Clinics;78: 100172, 2023. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1439912
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

The accuracy of diagnosis and the safety of treatment in colonoscopy depends largely on the quality of bowel cleansing. This study aimed to compare the efficacy and adverse reactions of Polyethylene Glycol (PEG) combined with lactulose with that of PEG alone in bowel preparation before colonoscopy.

Methods:

The authors searched a number of databases including EMBASE, MEDLINE, Cochrane Library, and China Academic Journals Full-text Database. The authors screened according to literature inclusion and exclusion criteria, assessed the quality of the included literature, and extracted the data. The meta-analysis of included literature used RevMan 5.3 and Stata 14.0 software.

Results:

A total of 18 studies, including 2274 patients, were enrolled. The meta-analysis showed that PEG combined with lactulose had a better efficacy (OR = 3.87, 95% CI 3.07‒4.87, p = 0.000, and I2 = 36.2% in the efficiency group; WMD = 0.86, 95% CI 0.69‒1.03, p = 0.032 and I2 = 0% in the BBPS score group) in bowel preparation for patients with or without constipation. Moreover, PEG combined with lactulose had fewer adverse reactions, including abdominal pain (OR = 1.42, 95% CI 0.94‒2.14, p = 0.094), nausea (OR = 1.60, 95% CI 1.13‒2.28, p = 0.009) and vomiting (OR = 1.77, 95% CI 1.14‒2.74, p = 0.011), than PEG alone. No significant reduction in the incidence of abdominal distention was observed.

Conclusion:

PEG combined with lactulose may be a better choice for bowel preparation before colonoscopy compared with PEG alone.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Systematic_reviews Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China / Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Systematic_reviews Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China / Estados Unidos País de publicação: Brasil