Immunohistochemical study of estrogen and progesterone receptors and cell proliferative indexes in canine inflammatory mammary carcinoma: 9 cases
Braz. j. vet. pathol
; 1(1): 16-20, 2008. ilus, tab
Article
em En
| VETINDEX
| ID: biblio-1435867
Biblioteca responsável:
BR68.1
ABSTRACT
Inflammatory mammary carcinoma (IMC) is a unique form of mammary cancer that affects women and female dogs. Hallmarks of IMC include clinical signs of inflammed affected glands and invasion of dermal lymphatics by tumor cells. Due to locally aggressive behavior and high metastatic rate, prognosis is considered poor. No satisfactory treatment has been suggested in veterinary medicine. The goal of this study was to evaluate the immunoreactivity for estrogen and progesterone receptors and cell proliferative indexes in nine cases of canine IMC. Estrogen and progesterone receptors were negative in all cases. For cell proliferative indexes, the mean number of neoplastic cells staining positive for Ki-67 and PCNA were 4.47% and 20.81%, respectively. Lack of estrogen and progesterone receptor expression, suggesting an undifferentiated phenotype, in conjunction with a relatively high proliferative capacity reflected by Ki-67 and PCNA staining are features typical of many clinically aggressive neoplasms, including canine IMC.
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Texto completo:
1
Base de dados:
VETINDEX
Assunto principal:
Receptores de Progesterona
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Receptores de Estrogênio
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Antígeno Nuclear de Célula em Proliferação
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Antígeno Ki-67
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Neoplasias Inflamatórias Mamárias
Limite:
Animals
Idioma:
En
Revista:
Braz. j. vet. pathol
Ano de publicação:
2008
Tipo de documento:
Article