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The effect of the tumor-to-skin distance on axillary lymph node metastasis in breast cancer
Yur, Mesut; Aygen, Erhan; İlhan, Yavuz Selim; Lale, Azmi; Ebiloğlu, Mehmet Fatih.
Afiliação
  • Yur, Mesut; Firat Üniversitesi. Department of Surgical Oncology. Elâzığ. TR
  • Aygen, Erhan; Firat Üniversitesi. Department of Surgical Oncology. Elâzığ. TR
  • İlhan, Yavuz Selim; Firat Üniversitesi. Department of Surgical Oncology. Elâzığ. TR
  • Lale, Azmi; Fethi Sekin State Hospital. Department of Surgical Oncology. Elâzığ. TR
  • Ebiloğlu, Mehmet Fatih; Firat Üniversitesi. Department of Surgical Oncology. Elâzığ. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);69(4): e20221277, 2023. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1431225
Biblioteca responsável: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

Tumor-to-skin distance is known to have an effect on axillary lymph node metastasis but has no clinical use with nomograms. This study aimed to investigate the effect of tumor-to-skin distance on axillary lymph node metastasis alone and in combination with nomogram for clinical use.

METHODS:

A total of 145 patients who underwent surgery for breast cancer (T1-T2 stage) and whose axillary lymph nodes were evaluated (axillary dissection or sentinel lymph node biopsy) between January 2010 and December 2020 were included in the study. Tumor-to-skin distance and other pathological data of the patients were evaluated.

RESULTS:

Of the 145 patients, 83 (57.2%) had metastatic lymph nodes in the axilla. Tumor-to-skin distance was different in terms of lymph node metastasis (p=0.045). In the receiver operating characteristic curve for tumor-to-skin distance, area under curve was 0.597 (95%CI 0.513-0.678, p=0.046), area under curve of the nomogram was 0.740 (95%CI 0.660-0.809), p<0.001) and nomogram+tumor-to-skin distance was 0.753 (95%CI 0.674-0.820), p<0.001). No statistical difference was found for axillary lymph node metastasis between the nomogram+tumor-to-skin distance and the nomogram alone (p=0.433).

CONCLUSION:

Although tumor-to-skin distance demonstrated a significant difference in axillary lymph node metastasis, it had a poor association with an area under curve value of 0.597 and did not produce a significant improvement in predicting lymph node metastasis when combined with the nomogram. The tumor-to-skin distance may be unlikely to enter clinical practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Prognostic_studies Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Prognostic_studies Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil