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TTYH3 is a prognostic biomarker and associates with immune cell infiltrations of lung adenocarcinoma / TTYH3 es un biomarcador pronóstico y se asocia con infiltraciones de células inmunitarias del adenocarcinoma de pulmón
Xu, Jian; Chen, Jiming; Duan, Honglu; Zhang, Dandan; Li, Yilu; Xu, Xiaoni; Li, Xiaoli.
Afiliação
  • Xu, Jian; Southern Medical University. Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Chen, Jiming; Huazhong University of Science and Technology Union Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Duan, Honglu; Southern Medical University. Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Zhang, Dandan; Southern Medical University. Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Li, Yilu; Huazhong University of Science and Technology Union Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Xu, Xiaoni; Huazhong University of Science and Technology Union Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
  • Li, Xiaoli; Southern Medical University. Shenzhen Hospital. Department of Respiratory and Critical Care Medicine. Shenzhen City. CN
Int. j. morphol ; 41(1): 118-133, feb. 2023. ilus, tab, graf
Article em En | LILACS | ID: biblio-1430508
Biblioteca responsável: CL1.1
ABSTRACT

SUMMARY:

We investigated Tweety Family Member 3 (TTYH3) level in lung adenocarcinoma (LUAD) and its relationship with immune infiltration in tumors by bioinformatics. Differential expressions of TTYH3 in lung cancer were analyzed with Oncomine, TIMER, GEO, UALCAN and HPA. Relationship of TTYH3 mRNA/protein levels with clinical parameters was analyzed by UALCAN. Co-expressed genes of TTYH3 in LUAD were analyzed using Cbioportal. Its relationship with LUAD prognosis was analyzed by Kaplan-Meier plotter. GO and KEGG analysis were performed. Correlation between TTYH3 and tumor immune infiltration were tested by TIMER, TISIDB and GEPIA. We found that TTYH3 was significantly increased in LUAD tissues. TTYH3 high expression was closely related to poor overall survival, post progression survival and first progression in LUAD patients. TTYH3 mRNA/protein levels were significantly associated with multiple pathways. Specifically, TTYH3 up-regulation was mostly related to biological regulation, metabolic process, protein blinding, extracellular matrix organization and pathways in cancer. Moreover, TTYH3 was positively associated with immune cell infiltration in LUAD. Finally, TTYH3 was highly expressed in LUAD as revealed by meta-analysis. TTYH3 is closely related to the prognosis of LUAD and immune cell infiltration, and it can be used as a prognostic biomarker for LUAD and immune infiltration.
RESUMEN
Investigamos por bioinformática el nivel de Tweety Family Member 3 (TTYH3) con adenocarcinoma de pulmón (LUAD) y su relación con la infiltración inmune en tumores. Las expresiones diferenciales de TTYH3 en cáncer de pulmón se analizaron con Oncomine, TIMER, GEO, UALCAN y HPA. Con UALCAN se analizó la relación de los niveles de ARNm/proteína de TTYH3 con los parámetros clínicos. Los genes coexpresados de TTYH3 en LUAD se analizaron utilizando Cbioportal. Su relación con el pronóstico LUAD se analizó mediante plotter de Kaplan- Meier. Se realizaron análisis GO y KEGG. TIMER, TISIDB y GEPIA probaron la correlación entre TTYH3 y la infiltración inmune tumoral. Encontramos que TTYH3 aumentó significativamente en los tejidos LUAD. La alta expresión de TTYH3 estuvo estrechamente relacionada con una supervivencia general deficiente, supervivencia posterior a la progresión y primera progresión en pacientes con LUAD. Los niveles de ARNm/ proteína de TTYH3 se asociaron significativamente con múltiples vías. Específicamente, la regulación positiva de TTYH3 se relacionó principalmente con la regulación biológica, el proceso metabólico, el cegamiento de proteínas, la organización de la matriz extracelular y las vías en el cáncer. Además, TTYH3 se asoció positivamente con la infiltración de células inmunitarias en LUAD. Finalmente, TTYH3 se expresó altamente en LUAD como lo reveló el metanálisis. TTYH3 está estrechamente relacionado con el pronóstico de LUAD y la infiltración de células inmunitarias, y se puede utilizar como biomarcador pronóstico para LUAD y la infiltración de células inmunitarias.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Canais de Cloreto / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int. j. morphol Assunto da revista: ANATOMIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Canais de Cloreto / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int. j. morphol Assunto da revista: ANATOMIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Chile