Systematic review on fecal calprotectin in cystic fibrosis
J. pediatr. (Rio J.)
; J. pediatr. (Rio J.);99(1): 4-10, Jan.-Feb. 2023. tab, graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1422020
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Objectives:
Fecal calprotectin is an inflammatory marker used for monitoring intestinal diseases. It has been studied as a marker of intestinal inflammation in cystic fibrosis (CF), a multi-systemic genetic disease caused by alterations to the CFTR gene. Manifestations of the disease favor a systemic inflammation not limited to the respiratory tract, therefore, calprotectin is a non-invasive and effective diagnostic method. The aim of the study was to perform a systematic review of the literature with a qualitative synthesis of studies. Sources The articles were selected from PubMed, Web of Science, Scielo and Lilacs. Summary of thefindings:
Nine studies were selected for that qualitative synthesis, one was a randomized clinical trial, and eight were case-control or cohort designs. Most studies have indicated that calprotectin is a marker of systemic inflammation in CF and not just intestinal inflammation. Calprotectin is an aid in monitoring inflammatory bowel conditions in patients with cystic fibrosis.Conclusion:
Further studies should be conducted to investigate the role of this marker in the systemic inflammation of CF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Tipo de estudo:
Clinical_trials
/
Qualitative_research
/
Systematic_reviews
Idioma:
En
Revista:
J. pediatr. (Rio J.)
Assunto da revista:
PEDIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil