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Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression
Oliveira, Scarlet Marques de; Garcia, Jéssica Leite; Vileigas, Danielle Fernandes; Campos, Dijon Henrique Salomé de; Francisqueti-Ferron, Fabiane Valentini; Ferron, Artur Junio Togneri; Silva-Bertani, Danielle Cristina Tomaz da; Padovani, Carlos Roberto; Corrêa, Camila Renata; Cicogna, Antonio Carlos.
Afiliação
  • Oliveira, Scarlet Marques de; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Garcia, Jéssica Leite; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Vileigas, Danielle Fernandes; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Campos, Dijon Henrique Salomé de; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Francisqueti-Ferron, Fabiane Valentini; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Ferron, Artur Junio Togneri; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Silva-Bertani, Danielle Cristina Tomaz da; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Padovani, Carlos Roberto; São Paulo State University. Institute of Bioscience. Botucatu. BR
  • Corrêa, Camila Renata; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Cicogna, Antonio Carlos; São Paulo State University. Botucatu Medical School. Botucatu. BR
Int. j. cardiovasc. sci. (Impr.) ; 34(6): 656-664, Nov.-Dec. 2021. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1421749
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive To evaluate if the cardiac remodeling was related to collagen protein expression change.

Methods:

Male Wistar rats were randomized into two experimental groups control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant.

Results:

The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups.

Conclusion:

The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Assunto da revista: CARDIOLOGIA Ano de publicação: 2021 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Assunto da revista: CARDIOLOGIA Ano de publicação: 2021 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil