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The effect of lithium tetraborate as a novel cardioprotective agent after renal ischemia-reperfusion injury
Koc, Kubra; Geyikoglu, Fatime; Yilmaz, Asli; Yildirim, Serkan; Deniz, Gulsah Yildiz.
Afiliação
  • Koc, Kubra; Ataturk University. Faculty of Science. Department of Biology. Erzurum. TR
  • Geyikoglu, Fatime; Ataturk University. Faculty of Science. Department of Biology. Erzurum. TR
  • Yilmaz, Asli; Ataturk University. Faculty of Science. Department of Molecular Biology and Genetics. Erzurum. TR
  • Yildirim, Serkan; Ataturk University. Faculty of Veterinary. Department of Pathology. Erzurum. TR
  • Deniz, Gulsah Yildiz; Ataturk University. Vocational School of Health Services. Erzurum. TR
Braz. J. Pharm. Sci. (Online) ; 58: e201052, 2022. graf
Article em En | LILACS | ID: biblio-1420425
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Abstract Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as an anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, we employed an in vivo rat model with kidney ischemia reperfusion injury to evaluate cardiac injury to clarify the mechanisms of lithium tetraborate. The evaluation of cardiac injury through kidney artery occlusion and reperfusion rat model indicated that lithium tetraborate could (1) reduce oxidative stress-induced endothelial dysfunction; (2) attenuate the inflammatory response of cardiac cells; and (3) alleviate the apoptosis and necrosis of myocytes. In summary, lithium tetraborate demonstrates significant therapeutic properties that contribute to the amelioration of cardiac damage, and it could be a promising candidate for future applications in myocardial dysfunction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Compostos de Boro / Cardiotônicos / Traumatismo por Reperfusão Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Compostos de Boro / Cardiotônicos / Traumatismo por Reperfusão Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil