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Maternal and perinatal outcomes in pregnant women with sickle cell disease: an update
Sousa, Viviane Teixeira de; Ballas, Samir K; Leite, Júlia Mota; Olivato, Maria Cristina Albe; Cancado, Rodolfo D.
Afiliação
  • Sousa, Viviane Teixeira de; Santa Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo. BR
  • Ballas, Samir K; Thomas Jefferson University. Cardeza Foundation for Hematologic Research. Philadelphia. US
  • Leite, Júlia Mota; Santa Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo. BR
  • Olivato, Maria Cristina Albe; Santa Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo. BR
  • Cancado, Rodolfo D; Santa Casa de São Paulo. Faculdade de Ciências Médicas. São Paulo. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 44(3): 369-373, July-Sept. 2022. tab
Article em En | LILACS | ID: biblio-1404996
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT
ABSTRACT

Introduction:

The aim of this study was to describe maternal and perinatal outcomes in pregnant women with sickle cell disease (SCD) followed at Santa Casa de Sao Paulo over a 10-year period (between 2010 and 2019).

Method:

Fifty-five records of pregnancies were analyzed among 35 women with SCD.

Results:

Among 29 newborns, 19 (65.5%) were full-term and 10 pre-term; 24 (82.7%) caesareans and 5 (17.2%) natural births were observed. The mean gestational age at birth and mother's age were 36.6 weeks (30-40) and 26.7 years (17-39), respectively. No maternal death was observed. The main maternal obstetric and non-obstetric complications were preeclampsia and gestational diabetes, and vaso-occlusive crisis, urinary tract infection and acute chest syndrome, respectively. Twenty-six (47.0%) fetal deaths were observed, 24 being intrauterine fetal (14 early abortions, 10 late abortions and 2 stillbirths). Regarding the red blood cell transfusion history, 40 (72.7%) out of 55 pregnancies received transfusion. Pregnant women who received 6 or more transfusions throughout pregnancy had a significantly lower number of abortions, i.e., no cases of early abortion and only 1 case of late abortion, versus 14 and 9 cases in pregnancies with 0-5 transfusions, respectively. Despite advances in the management of SCD, pregnant women with SCD (particularly those with HbSS) are at a high risk for maternal and fetal complications, even though they are followed in reference centers.

Conclusion:

The lower risk of intrauterine fetal death for those women who received more transfusions throughout pregnancy observed in the current study leads us once more to raise the need for prospective, multicenter, randomized trials to determine whether the potential benefits balance the risks of prophylactic transfusions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Gravidez / Anemia Falciforme Tipo de estudo: Clinical_trials Limite: Female / Humans / Pregnancy Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil / Estados Unidos País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Gravidez / Anemia Falciforme Tipo de estudo: Clinical_trials Limite: Female / Humans / Pregnancy Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil / Estados Unidos País de publicação: Brasil