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Development and optimization of cosolvent-based blended Sertraline orodispersible films - A step to personalized medicine
Abouhussein, Dalia M N; Nabarawi, Mohamed A El; Shalaby, Samia H; El-Bary, Ahmed Abd.
Afiliação
  • Abouhussein, Dalia M N; Egyptian Drug Authority. Department of Pharmaceutics. EG
  • Nabarawi, Mohamed A El; Cairo University. Faculty of Pharmacy. Department of Pharmaceutics and Industrial Pharmacy. Cairo. EG
  • Shalaby, Samia H; Egyptian Drug Authority. Department of Pharmaceutics. EG
  • El-Bary, Ahmed Abd; Cairo University. Faculty of Pharmacy. Department of Pharmaceutics and Industrial Pharmacy. Cairo. EG
Braz. J. Pharm. Sci. (Online) ; 58: e20584, 2022. tab, graf
Article em En | LILACS | ID: biblio-1403761
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Abstract Personalized medicine is gaining importance in pharmacotherapeutics as it allows tailoring the drug treatment to achieve the best patient response. Orodispersible film (ODF) is easy to formulate in hospitals, produces dose flexibility to suit an individual needs, particularly for patients suffer from swallowing issues or prohibited to take fluids. Sertraline Hydrochloride (SRT) was solubilized in several cosolvents, then different SRT ODFs based on five hydrophilic polymers namely; polyvinyl alcohol (PVA), hydroxylethyl cellulose (HEC), hydroxypropyl methylcellulose E5 LV (HPMC E5 LV), sodium alginate (NaAlg) and gelatin at two concentrations (2% and 4%) were developed and characterized. The outcomes were exposed to response surface analysis to obtain the desirability results to obtain the optimized formulation. Blended ODFs were developed from 4% PVA and 2% HEC in different blends and then potassium chloride (KCl) as a pore-forming agent was added to the best formulation to investigate its dissolution enhancement effect. F14 containing 4% PVA 2% HEC 21 with 5% KCl showed best physicochemical properties of suitable pH (5.6), disintegration time (6 sec), good folding endurance which released 91 % SRT after 15 min. SRT ODF is an encouraging delivery system in the course of personalized medicine for the management of depression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Solventes / Sertralina / Medicina de Precisão Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Solventes / Sertralina / Medicina de Precisão Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil