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A novel approach to Cestrum intermedium (mata-boi): anatomical and physical-chemical characterization, in vitro biological activities, and metabolites of a Brazilian native species
Szabo, Ellis Marina; Deffert, Flavia; Barbosa, Vanessa; Rech, Katlin Suellen; Homem, Isabel Christina Mignoni; Silva, Cristiane Bezerra da; Oliveira, Vinícius Bednarczuk de; Miguel, Marilis Dallarmi; Miguel, Obdulio Gomes.
Afiliação
  • Szabo, Ellis Marina; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Deffert, Flavia; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Barbosa, Vanessa; Campos Gerais College. Department of Pharmacy. Ponta Grossa. BR
  • Rech, Katlin Suellen; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Homem, Isabel Christina Mignoni; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Silva, Cristiane Bezerra da; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Oliveira, Vinícius Bednarczuk de; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Miguel, Marilis Dallarmi; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Miguel, Obdulio Gomes; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20149, 2022. tab, graf
Article em En | LILACS | ID: biblio-1403746
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Abstract The Brazilian native species Cestrum intermedium, known as mata-boi, induces hepatotoxicity and death when ingested by cattle. While most studies on this species focus on toxicological features, our study is the first to describe the anatomy and in vitro biological activities of Cestrum intermedium. We investigated adult leaves and stems by histochemistry, described their anatomy, performed physical-chemical analysis, determined in vitro antioxidant and antimicrobial activities, and identified secondary metabolites. A few noteworthy anatomical features were the anomocytic stomata on the abaxial surface and the absence of trichomes, in addition to the circular shaped petiole with two projections on the adaxial surface. Histochemical analysis showed chemical markers such as alkaloids, usually reported as toxic, and terpenoids. Potassium nitrate (ATR-FTIR) and lupeol palmitate (NMR) were detected on the crude stem extract. Thermogravimetric and physical-chemical analysis provided fingerprint parameters for the species. Minimal Inhibitory Concentration (MIC) assay revealed that Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans were weakly inhibited by extract samples. Chloroform and ethyl acetate fractions presented high phenolic content, which resulted in in vitro antioxidant activity. These novel features expand the knowledge about this species, considering that previous studies mainly focused on its toxicity. Our study also provided characteristics that may help in avoiding misidentification between Cestrum members, especially when taxonomic keys cannot be employed, as in the absence of flowers and fruits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Técnicas In Vitro / Solanaceae Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Técnicas In Vitro / Solanaceae Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil