Your browser doesn't support javascript.
loading
Treatment of colitis by oral negatively charged nanostructured curcumin in rats
Celani, Lívia Medeiros Soares; Egito, Eryvaldo Sócrates Tabosa; Azevedo, Ítalo Medeiros; Oliveira, Cláudia Nunes; Dourado, Douglas; Medeiros, Aldo Cunha.
Afiliação
  • Celani, Lívia Medeiros Soares; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Egito, Eryvaldo Sócrates Tabosa; Universidade Federal do Rio Grande do Norte. Laboratory of Dispersed Systems. Natal. BR
  • Azevedo, Ítalo Medeiros; Universidade Federal do Rio Grande do Norte. Health Sciences. Natal. BR
  • Oliveira, Cláudia Nunes; Universidade Federal do Rio Grande do Norte. Pathology Department. Health Sciences. Natal. BR
  • Dourado, Douglas; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Medeiros, Aldo Cunha; Universidade Federal do Rio Grande do Norte. Nucleus of Experimental Surgery. Natal. BR
Acta cir. bras ; 37(6): e370602, 2022. tab, ilus
Article em En | VETINDEX | ID: biblio-1393762
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To examine the effects of a negatively charged nanostructured curcumin microemulsion in experimental ulcerative colitis (UC) in rats.

Methods:

Four percent acetic acid was used to induce UC. The animals were treated for seven days and randomly assigned to four groups normal control (NC), colitis/normal saline (COL/NS), colitis/curcumin (COL/CUR), and colitis/mesalazine (COL/MES). The nanostructured curcumin was formulated with a negative zeta potential (-16.70 ± 1.66 mV). Dosage of the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin 1-ß (IL-1ß), interleukin 6 (IL-6), and antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase), macro and microscopic evaluation of the colon tissue were analyzed.

Results:

The COL/CUR group had a higher level of antioxidant enzymes compared to the COL/MESgroup. The levels of TNF-α, IL-1ß and IL-6 were significantly lower in the colonic tissue of the COL/CUR group rats, when compared to the COL/NS and COL/MES groups (p < 0.001). The presence of ulcers in the colonic mucosa in rats of the COL/NSgroup was significantly higher than in the COL/MES group (p < 0.001). In the NC and COL/CUR groups, there were no ulcers in the colonic mucosa.

Conclusions:

The nanostructured microemulsion of curcumin, used orally, positively influenced the results of the treatment of UC in rats. The data also suggests that nanostructured curcumin with negative zeta potential is a promising phytopharmaceutical oral delivery system for UC therapy. Further research needs to be done to better understand the mechanisms of the negatively charged nanostructured curcumin microemulsion in UC therapy.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Colite Ulcerativa / Curcumina / Inflamação / Fitoterapia / Mucosa Limite: Animals Idioma: En Revista: Acta cir. bras Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Colite Ulcerativa / Curcumina / Inflamação / Fitoterapia / Mucosa Limite: Animals Idioma: En Revista: Acta cir. bras Ano de publicação: 2022 Tipo de documento: Article