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Comparison of the effects of duloxetine and pregabalin on pain and associated factors in patients with knee osteoarthritis
Illeez, Ozge Gulsum; Oktay, Kubra Neslihan Kurt; Aktas, Ilknur; Ozkan, Feyza Unlu; Nazligül, Tuba; Begoglu, Feyza Akan; Kaysin, Meryem Yilmaz; Atici, Arzu; Akpinar, Pinar.
Afiliação
  • Illeez, Ozge Gulsum; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Oktay, Kubra Neslihan Kurt; Yeditepe University Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Aktas, Ilknur; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Ozkan, Feyza Unlu; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Nazligül, Tuba; University of Health Sciences. Van Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Van. TR
  • Begoglu, Feyza Akan; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Kaysin, Meryem Yilmaz; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Atici, Arzu; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
  • Akpinar, Pinar; University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital. Department of Physical Medicine and Rehabilitation. Istanbul. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);68(3): 377-383, Mar. 2022. tab
Article em En | LILACS-Express | LILACS | ID: biblio-1376130
Biblioteca responsável: BR1.1
ABSTRACT
SUMMARY

OBJECTIVES:

This study aimed to investigate the effects of duloxetine and pregabalin primarily on pain and functional status in patients with knee osteoarthritis and secondarily on quality of life, depression, anxiety, and sleep disturbance.

METHODS:

A total of 66 patients with knee osteoarthritis were randomized to use duloxetine or pregabalin. Patients were evaluated by Visual Analog Scale, Neuropathic Pain Diagnostic Questionnaire, Western Ontario and McMaster University Osteoarthritis Index, Short Form-36, Beck Depression Inventory, Beck Anxiety Inventory, and Pittsburg Sleep Quality Index before the treatment and after 4 and 12 weeks of treatment.

RESULTS:

Improvements occurred in Visual Analog Scale, Neuropathic Pain Diagnostic Questionnaire, Western Ontario and McMaster University Osteoarthritis Index, Short Form-36 (with an exception of the mental health subgroup scores in duloxetine-treated group), Beck Depression Inventory, and Beck Anxiety Inventory scores in both groups from 4 weeks after baseline. Pittsburg Sleep Quality Index total scores and SF-36 mental health subgroup scores started to improve on the 4th and 12th weeks in pregabalin- and duloxetine-treated groups, respectively.

CONCLUSION:

Osteoarthritis pain, a complex outcome with nociceptive and neuropathic components, leads to central sensitization in a chronic phase. Using centrally acting drugs in the control of pain and associated symptoms would increase the probability of treatment success.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Clinical_trials / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Clinical_trials / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil