Your browser doesn't support javascript.
loading
Analysis of the related risk factors of inguinal lymph node metastasis in patients with penile cancer: A cross-sectional study
Jia, Yatao; Zhao, Hongwei; Hao, Yun; Zhu, Jiang; Li, Yingyi; Wang, Yanbo.
Afiliação
  • Jia, Yatao; Baoji Peoples Hospital. Department of Urology. Baoji. CN
  • Zhao, Hongwei; The First Hospital of Jilin University. Department of Neurology. Changchun. CN
  • Hao, Yun; Jilin University First Hospital Branch. Department of Nephrology. Changchun. CN
  • Zhu, Jiang; Baoji Peoples Hospital. Department of Urology. Baoji. CN
  • Li, Yingyi; Baoji Peoples Hospital. Department of Urology. Baoji. CN
  • Wang, Yanbo; The First Hospital of Jilin University. Department of Urology. Changchun. CN
Int. braz. j. urol ; 48(2): 303-313, March-Apr. 2022. tab, graf
Article em En | LILACS | ID: biblio-1364958
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Purpose:

To determine independent predictors of inguinal lymph node (ILN) metastasis in patients with penile cancer. Patients and

methods:

We retrospectively analyzed all patients with penile cancer who underwent surgery at our medical center in the last ten years (n=157). Using univariate and multivariate logistic-regression models, we assessed associations with age, medical-history, phimosis, onset-time, number and maximum diameter of involved ILNs measured by imaging, pathological T stage, degree of tumor differentiation and/or cornification, lymphatic vascular infiltration (LVI), nerve infiltration, and ILN metastases. Interaction and stratified analyses were used to assess age, phimosis, onset time, number of ILNs, cornification, and nerve infiltration.

Results:

A total of 110 patients were included in the study. Multiple logistic regression analysis showed that the following factors were significantly correlated with ILN metastasis maximum diameter of enlarged ILNs, T stage, pathological differentiation, and LVI. Among patients with a maximum ILN diameter ≥1.5cm, 50% had lymph node metastasis whereas 30.6% patients with a maximum ILN diameter <1.5cm showed LNM. Among 44 patients with stage Ta/T1, 10 showed ILN metastases, while 47.0% patients with stage T2 showed ILN metastases. Among 40 patients with highly differentiated penile-cancer, eight showed ILN metastasis, while 47.1% patients with low-to-middle differentiation showed ILN metastases. The rate of LNM was 33.3% in the LVI-free group and 64.3% in the LVI group.

Conclusion:

Our single-center results suggested that maximum ILN diameter, pathological T stage, pathological differentiation, and LVI were independent risk factors for ILN metastases.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Penianas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Penianas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Brasil