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Antibody response against SARS-CoV-2 in convalescent plasma donors: Can we predict subjects' eligibility?
Prudente, Tiago Paiva; Castro, Renato Gomes; Candido, Marcos Antonio; Rodrigues, Roberta Luiza; Souza, Layane Marques de; Roberti, Maria do Rosario Ferraz.
Afiliação
  • Prudente, Tiago Paiva; Universidade Federal de Goiás - UFG. Faculdade de Medicina. Goiânia. BR
  • Castro, Renato Gomes; Universidade Federal de Goiás - UFG. Faculdade de Medicina. Goiânia. BR
  • Candido, Marcos Antonio; Universidade Federal de Goiás - UFG. Faculdade de Medicina. Goiânia. BR
  • Rodrigues, Roberta Luiza; Universidade Federal de Goiás - UFG. Faculdade de Medicina. Goiânia. BR
  • Souza, Layane Marques de; Hemocentro de Goiás - HEMOGO. Goiânia. BR
  • Roberti, Maria do Rosario Ferraz; Universidade Federal de Goiás - UFG. Faculdade de Medicina. Goiânia. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 44(1): 1-6, Jan.-Mar. 2022. tab, graf
Article em En | LILACS | ID: biblio-1364895
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT
Abstract Introduction As the Coronavirus Disease 2019 (COVID-19) pandemic unfolds around the world; answers related to the antibody response against the virus are necessary to develop treatment and prophylactic strategies. We attempted to understand part of the immune response of convalescent plasma donation candidates. Method We carried out a cross-sectional, observational, non-intervention study, testing 102 convalescent plasma donation candidates for antibodies against the virus, relating these data to the time interval between symptom onset and sample collection, age, disease severity, and gender. Results In our sample, the individuals who developed a greater antibody response were the ones who had a longer time interval between symptom onset and sample collection, the ones who had been hospitalized and the subjects above 35 years old. Moreover, 17 individuals did not present any reactive antibodies. Conclusion These results are important in that they raise questions about the role of the humoral response against the virus, as some individuals do not develop antibodies to fight it. In addition, they help develop recruitment strategies for convalescent plasma donors, who should be asymptomatic for at least 21 days and are possibly more likely to have reactive antibodies after 35 days without symptoms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por Coronavirus / Teste Sorológico para COVID-19 / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por Coronavirus / Teste Sorológico para COVID-19 / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil