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Anti-hyperlipidemic and anti-diabetic evaluation of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy
Azam, Khadija; Rasheed, Muhammad Adil; Omer, Muhammad Ovais; Altaf, Imran; Akhlaq, Amina.
Afiliação
  • Azam, Khadija; University of Veterinary and Animal Sciences Lahore. Department of Pharmacology & Toxicology. Punjab. PK
  • Rasheed, Muhammad Adil; University of Veterinary and Animal Sciences Lahore. Department of Pharmacology & Toxicology. Punjab. PK
  • Omer, Muhammad Ovais; University of Veterinary and Animal Sciences Lahore. Department of Pharmacology & Toxicology. Punjab. PK
  • Altaf, Imran; University Of Veterinary and Animal Sciences Lahore. Department of Microbiology. Punjab. PK
  • Akhlaq, Amina; University of Veterinary and Animal Sciences Lahore. Department of Pharmacology & Toxicology. Punjab. PK
Braz. J. Pharm. Sci. (Online) ; 58: e18672, 2022. tab, graf
Article em En | LILACS | ID: biblio-1360164
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
The use of plants in disease treatment is cost effective and relatively safe. This study was designed to investigate anti-hyperlipidemic and anti-diabetic activity of ethanolic leaf extract of Catharanthus roseus alone and in combination therapy in hyperlipidemic & diabetic mice. Eight groups comprising five mice each were used. Group A was hyperlipidemic control, group B, C, D received atorvastatin (20 mg/kg), leaf extract (200 mg/kg) and leaf extract in combination with atorvastatin (200 mg/kg and 20 mg/kg) orally for 15 days. Group E was diabetic control. Group F, G, H received sitagliptin (40 mg/kg), leaf extract (200 mg/kg) and extract in combination with sitagliptin (200 mg/kg and 40 mg/kg) orally for 7 days. Blood cholesterol levels were measured at 1st, 5th, 10th and 15th day and fasting blood sugar levels were measured at 2, 12, 24, 72 and 168 hours during treatment. One-way ANOVA with tukey- kramer multiple comparison test was used. The chemical characterization of ethanolic extract of Catharanthus roseus leaves showed presence of alkaloids, saponins, tannins and flavonoids. Ethanolic extract of Catharanthus roseus has significant anti-hyperlipidemic & anti-diabetic effects (p<0.05, p<0.01) when compared with control but had not cause significantly increase in anti-hyperlipidemic effects of atorvastatin. While significantly increased the antidiabetic effect of sitagliptin (p<0.05)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Folhas de Planta / Catharanthus / Hipoglicemiantes Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Folhas de Planta / Catharanthus / Hipoglicemiantes Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão País de publicação: Brasil