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Decreased ovarian reserve and ovarian morphological alterations in female rat offspring exposed to a ketogenic maternal diet
Budak, Özcan; Bostanci, Mehmet Sühha; Kurtoglu, Erdal; Toprak, Veysel.
Afiliação
  • Budak, Özcan; Sakarya University. Faculty of Medicine. Department of Histology and Embryology and Artificial Reproductive Techniques. Sakarya. TR
  • Bostanci, Mehmet Sühha; Sakarya University. Faculty of Medicine. Department of Obstetrics and Gynecology and Artificial Reproductive Techniques. Sakarya. TR
  • Kurtoglu, Erdal; Erciyes University. Faculty of Medicine. Department of Anatomy. Kayseri. TR
  • Toprak, Veysel; Private Tatvan Can Hospital. Department of Obstetrics and Gynecology. Bitlis. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);67(10): 1415-1420, Oct. 2021. graf
Article em En | LILACS | ID: biblio-1351432
Biblioteca responsável: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

This study evaluates the effects of a ketogenic diet on morphology and follicle reserve.

METHOD:

Sixteen Sprague-Dawley rats were randomized into two groups standard diet group (n=8) and ketogenic diet group (n=8). Rats were time mated. Dams were permitted to deliver spontaneously. The animals were monitored for the onset of puberty. All the rats were weighed and anesthetized, serum anti-Müllerian hormone level was measured, and the oviducts were removed. The morphological characteristics of follicles were determined and total ovarian volumes were calculated.

RESULTS:

The mean ovarian volume was statistically significantly lower in the ketogenic diet group compared to the standard diet group (14.41±0.99 mm3 versus 18.89±1.28 mm3) (p=0.000). The mean number of antral follicles was 13.63±1.80 in the standard diet group and 4.462±0.760 in the ketogenic diet group. The mean ovarian weight of the ketogenic diet group was significantly lower than that of the standard diet group (0.42±0.06 g versus 0.815±107 g). The mean anti-Müllerian hormone levels were significantly higher in the standard diet group compared to the ketogenic diet group (1.023±4.75 ng/mL versus 0.69±0.07 ng/mL) (p=0.000). The mean percentage of staining of Ki-67 was 35.28±4.75 in the standard diet group and 16.98±3.33 in the ketogenic diet group (p=0.000).

CONCLUSION:

Maternal ketogenic diet reduces ovarian follicular reserve in female offspring and has important implications for maintaining reproductive potential at a population level.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Dieta Cetogênica / Reserva Ovariana Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Dieta Cetogênica / Reserva Ovariana Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil