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Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population
Faramarzi, Elnaz; Aftabi, Younes; Ansarin, Khalil; Somi, Mohammad Hossein; Gilani, Neda; Seyedrezazadeh, Ensiyeh.
Afiliação
  • Faramarzi, Elnaz; Tabriz University of Medical Sciences. Liver and Gastrointestinal Diseases Research Center. Tabriz. IR
  • Aftabi, Younes; Tabriz University of Medical Sciences. Tuberculosis and Lung Diseases Research Center. Tabriz. IR
  • Ansarin, Khalil; Tabriz University of Medical Sciences. Tuberculosis and Lung Diseases Research Center. Tabriz. IR
  • Somi, Mohammad Hossein; Tabriz University of Medical Sciences. Liver and Gastrointestinal Diseases Research Center. Tabriz. IR
  • Gilani, Neda; Tabriz University of Medical Sciences. Faculty of Health. Department of Statistics and Epidemiology. Tabriz. IR
  • Seyedrezazadeh, Ensiyeh; Tabriz University of Medical Sciences. Tuberculosis and Lung Diseases Research Center. Tabriz. IR
Arch. endocrinol. metab. (Online) ; 65(4): 443-449, July-Aug. 2021. tab
Article em En | LILACS | ID: biblio-1339107
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Objective:

Globally developing metabolic syndrome (MetS) prevalence as a major health problem can be related to multiple factors of genetic and environmental. Dimethylaminohydrolase 2 (DDAH2) is the main enzyme implicated in the cardiovascular system, which regulates the nitric oxide pathway. This study investigated the association of DDAH2 polymorphism −499C/G (rs805305) with the risk of MetS among the Azar-Cohort population. Subjects and

methods:

The occurrence of SNP rs805305 in the DDAH2 gene was tested using the PCR-RFLP method in 332 MetS cases and 294 healthy controls. Afterward, the association of the allele and genotypes with the risk of MetS and its components were examined.

Results:

The G allele and GC genotype were significantly associated with a reduced risk of MetS (P ≤ 0.001). Also, the dominant genetic model (GG+GC) significantly decreased the risk of MetS (P = 0.001), however, in sex subtypes MetS risk was significantly reduced in males before and in females after adjustment for age (P ≤ 0.02).

Conclusion:

The −499C/G polymorphism of DDAH2 may play a protective role and reduce MetS risk among the Azar-Cohort population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Síndrome Metabólica / Amidoidrolases Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Síndrome Metabólica / Amidoidrolases Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil