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Polymorphisms in ß-adrenergic receptors are associated with increased risk to have a positive head-up tilt table test in patients with vasovagal syncope
Márquez, Manlio F.; Fragoso, José Manuel; Pérez-Pérez, Daniel; Cázares-Campos, Iris; Totomoch-Serra, Armando; Gómez-Flores, Jorge Rafael; Vargas-Alarcón, Gilberto.
Afiliação
  • Márquez, Manlio F.; Instituto Nacional de Cardiología Ignacio Chávez. Department of Electrophysiology. Mexico City. MX
  • Fragoso, José Manuel; Instituto Nacional de Cardiología Ignacio Chávez. Department of Molecular Biology. Mexico City. MX
  • Pérez-Pérez, Daniel; Instituto Nacional de Cardiología Ignacio Chávez. Department of Electrophysiology. Mexico City. MX
  • Cázares-Campos, Iris; Instituto Nacional de Cardiología Ignacio Chávez. Department of Electrophysiology. Mexico City. MX
  • Totomoch-Serra, Armando; Instituto Politécnico Nacional. Centro de Investigación y Estudios Avanzados. Mexico City. MX
  • Gómez-Flores, Jorge Rafael; Instituto Nacional de Cardiología Ignacio Chávez. Department of Electrophysiology. Mexico City. MX
  • Vargas-Alarcón, Gilberto; Instituto Nacional de Cardiología Ignacio Chávez. Department of Molecular Biology. Mexico City. MX
Rev. invest. clín ; Rev. invest. clín;71(2): 124-132, Mar.-Apr. 2019. tab
Article em En | LILACS | ID: biblio-1289678
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Background Vasovagal syncope (VVS) is a frequent clinical condition in which a genetic background seems to be implicated. Considering that the adrenergic receptors (ARs) may play a role in VVS, the present study has as principal aim to determine if the α- and β-AR (ADRA and ADRB) gene polymorphisms are associated with an increased risk to have a positive head-up tilt table (HUTT) test in patients with VVS.

Methods:

Nine polymorphisms in the ADRA1A (rs1048101, rs1383914, rs574584, and rs573542), ADRB1 (rs1801252 and rs1801253), ADRB2 (rs1042713 and rs1042714), and ADRB3 (rs4994) genes were analyzed using the 5’ exonuclease TaqMan genotyping assay in a group of 134 patients with VVS. Results Under different models, the rs1801252 (OR = 8.63, 95% CI 0.95-78.72, Precessive = 0.02), rs1042713 (OR = 1.94, 95% CI 1.02-3.66, Padditive = 0.04), and rs4994 (OR = 2.46, 95% CI 1.01-6.01, Pdominant = 0.042 and OR = 2.62, 95% CI 1.04-6.63, Pover-dominant = 0.03) polymorphisms were associated with increased risk for a positive HUTT. All models were adjusted for statistically significant covariates. Conclusion These results suggest that some polymorphisms of the β-AR genes could contribute to a positive tilt test in patients with VVS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Receptores Adrenérgicos beta / Teste da Mesa Inclinada / Síncope Vasovagal Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Rev. invest. clín Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Receptores Adrenérgicos beta / Teste da Mesa Inclinada / Síncope Vasovagal Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Rev. invest. clín Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México País de publicação: México