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Role of genetic susceptibility in nicotine addiction and chronic obstructive pulmonary disease
Pérez-Rubio, Gloria; Córdoba-Lanús, Elizabeth; Cupertino, Paula; Cartujano-Barrera, Francisco; Campos, Michael A.; Falfán-Valencia, Ramcés.
Afiliação
  • Pérez-Rubio, Gloria; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. HLA Laboratory. Mexico City. MX
  • Córdoba-Lanús, Elizabeth; Hospital Universitario Nª Sª de Candelaria. Research Unit. Santa Cruz de Tenerife. ES
  • Cupertino, Paula; Hackensack University Medical Center. Department of Cancer Prevention Control. New Jersey. US
  • Cartujano-Barrera, Francisco; Hackensack University Medical Center. Department of Cancer Prevention Control. New Jersey. US
  • Campos, Michael A.; University of Miami Health System. Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine. FL. US
  • Falfán-Valencia, Ramcés; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas. HLA Laboratory. Mexico City. MX
Rev. invest. clín ; Rev. invest. clín;71(1): 36-54, Jan.-Feb. 2019. graf
Article em En | LILACS | ID: biblio-1289668
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in developed countries. Although cigarette smoking is the major risk factor, only 10-20% of smokers develop COPD. The extent of cigarette smoking (pack-years and smoking duration) accounts for only 15% of the variation in lung function, indicating that differences in susceptibility to COPD must exist. We provide an overview of the complexity of nicotine addiction and COPD, with special attention to the involvement of genetic factors. The following aspects are discussed in the present article (1) epidemiology in Mexico and (2) a review of the published literature on genetic association studies using the National Center for Biotechnology Information database of the United States as a search tool. COPD is unique among complex genetic diseases where an environmental risk factor is known and the level of exposure can be documented with some precision. The high morbidity and mortality associated with COPD and its chronic and progressive nature has prompted the use of molecular genetic studies to identify susceptibility factors for the disease. Biomedical research has a remarkable set of tools to aid in the discovery of genes and polymorphisms. We present a review of the most relevant genetic associations in nicotine addiction and COPD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tabagismo / Predisposição Genética para Doença / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: Rev. invest. clín Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México / Espanha / Estados Unidos País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tabagismo / Predisposição Genética para Doença / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: Rev. invest. clín Assunto da revista: MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México / Espanha / Estados Unidos País de publicação: México