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External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies
Nowrin, Shifat A; Jaafar, Saidi; Rahman, Norma Ab; Shahid, Fazal; Basri, Rehana; Alam, Mohammad Khursheed.
Afiliação
  • Nowrin, Shifat A; Universiti Sains Malaysia. School of Dental Sciences. Orthodontic Unit. Kubang Kerian. MY
  • Jaafar, Saidi; Universiti Sains Malaysia. School of Dental Sciences. Craniofacial Biology Research Group. Kubang Kerian. MY
  • Rahman, Norma Ab; Universiti Sains Malaysia. School of Dental Sciences. Orthodontic Unit. Kubang Kerian. MY
  • Shahid, Fazal; Universiti Sains Malaysia. School of Dental Sciences. Orthodontic Unit. Kubang Kerian. MY
  • Basri, Rehana; Jouf University. College of Medicine. Department of Medicine. Sakaka. SA
  • Alam, Mohammad Khursheed; Jouf University. College of Dentistry. Orthodontic Unit. Sakaka. SA
Pesqui. bras. odontopediatria clín. integr ; 21: e0217, 2021. tab, graf
Article em En | LILACS, BBO | ID: biblio-1250442
Biblioteca responsável: BR1264.1
ABSTRACT
ABSTRACT

Objective:

To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR. Material and

Methods:

The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020.

Results:

A total of 13 and 9 publications were selected for the systematic review and meta-analysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR.

Conclusion:

More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Ortodontia / Polimorfismo Genético / Reabsorção da Raiz / Heterogeneidade Genética / Proteína Antagonista do Receptor de Interleucina 1 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews País/Região como assunto: Asia Idioma: En Revista: Pesqui. bras. odontopediatria clín. integr Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Malásia / Arábia Saudita País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Ortodontia / Polimorfismo Genético / Reabsorção da Raiz / Heterogeneidade Genética / Proteína Antagonista do Receptor de Interleucina 1 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews País/Região como assunto: Asia Idioma: En Revista: Pesqui. bras. odontopediatria clín. integr Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Malásia / Arábia Saudita País de publicação: Brasil