Gummatous cutaneous tuberculosis associated with the use of infliximab for Crohn's disease

Dermatology ServiceGarcia, Lucas Campos; Dermatology ServiceVale, Everton Carlos Siviero do; Department of GastroenterologyFerrari, Maria de Lourdes; Department of GastroenterologyFaria, Lauro Damasceno de Carvalho

Dermatology ServiceGarcia, Lucas Campos; Dermatology ServiceVale, Everton Carlos Siviero do; Department of GastroenterologyFerrari, Maria de Lourdes; Department of GastroenterologyFaria, Lauro Damasceno de Carvalho.

Afiliação

Dermatology ServiceGarcia, Lucas Campos; Universidade Federal de Minas Gerais. Hospital das Clínicas. Dermatology ServiceGarcia, Lucas Campos. Belo Horizonte. BR
Dermatology ServiceVale, Everton Carlos Siviero do; Universidade Federal de Minas Gerais. Hospital das Clínicas. Dermatology ServiceVale, Everton Carlos Siviero do. Belo Horizonte. BR
Department of GastroenterologyFerrari, Maria de Lourdes; Universidade Federal de Minas Gerais. Faculty of Medicine. Department of GastroenterologyFerrari, Maria de Lourdes. Belo Horizonte. BR
Department of GastroenterologyFaria, Lauro Damasceno de Carvalho; Universidade Federal de Minas Gerais. Faculty of Medicine. Department of GastroenterologyFaria, Lauro Damasceno de Carvalho. Belo Horizonte. BR

An. bras. dermatol ; An. bras. dermatol;96(2): 228-230, Mar.-Apr. 2021. graf

Article em En | LILACS | ID: biblio-1248737

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

Abstract As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.

Assuntos

Humanos; Tuberculose Cutânea/diagnóstico; Tuberculose Cutânea/induzido quimicamente; Tuberculose Cutânea/tratamento farmacológico; Doença de Crohn/tratamento farmacológico; Sífilis; Pele; Infliximab/efeitos adversos

Palavras-chave

Crohn's disease; Molecular target therapy; Skin tuberculosis; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Tuberculose Cutânea / Doença de Crohn / Sífilis Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: An. bras. dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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