Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in Brazilian cohort
s.l; s.n; 2004. 6 p. ilus, tab.
Non-conventional
em En
| SES-SP, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1241644
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "09233/s"}]
ABSTRACT
Co-infections with human immunodeficiency virus (HIV) and Mycobacterium leprae represent unique opportunities to investigate the interaction of both pathogens. We determined the immunologic, virologic, and histopathologic characteristics of 22 co-infected Brazilian patients (median age = 38 years, 81.8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome). The HIV-1 subtypes B and BF predominated in envelope and gag heteroduplex mobility analysis. Borderline tuberculoid (BT), tuberculoid, lepromatous, and indeterminate morphology with CD3+, CD8+, and CD68+ cell distributions compatible with leprosy patients not infected with HIV were observed. Histologic evidence of nerve damage was observed in BT lesions. IgM antibody to M. leprae-specific phenolic glycolipid I was not detected. Two of six co-infected patients monitored during highly active antiretroviral therapy (HAART) developed a leprosy type 1 reaction after an increase in CD4+ cells, suggesting an immune restoration phenomenon. Clinical, immunologic, histopathologic, and virologic features among these HIV-leprosy co-infected patients indicate that each disease progressed as in single infection. However, HAART immune reconstitution may trigger potential adverse effects, such as leprosy acute inflammatory episodes
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
DNA Viral
/
Comorbidade
/
Infecções por HIV
/
Estudos de Coortes
/
HIV-1
/
Hanseníase
/
Anticorpos Antibacterianos
/
Mycobacterium leprae
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Non-conventional