Tuberculization and reactivity to lepromin. Association between lepromin and tuberculin reactions in schoool children in Cordova and opon Cebu, Philippines
Int. j. lepr
; 23(1): 32-47, Jan.-Mar. 1955. tab
Article
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1227527
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1"}]
ABSTRACT
1- A study has been made of the association between the reactions to tuberculin (first and second strength PPD) and early and late reactions to lepromin in 544 children of ages 7 to 9, inclusive, attending public schools in Cordova and Opon, Mactan Island, Cebu. In these municipalities the prevalence of leprosy is about 20 per 1,000 of which one-third is of the lepromatous type. Tuberculosis is known to be frequent. 2- The following percentages were positive First PPD, 14.0; first and second PPD, 71.9; early lepromin (Fernandez), 4.4; and late lepromin (Mitsuda), 65.3. 3- Only 24 children showed an early lepromin reaction of 10 mm. or larger with infiltration. All of these had typical late reactions. Eight of the 24 were positive to first strength PPD; all of the remaining 16 reacted to the second strength. 4- The occurrence and intensity of the Mitsuda reaction were positively associated with occurrence and intensity of reaction to PPD. If it be granted that a high proportion of reactions to the second strength PPD were attributable to infection with the tubercle bacillus, then tuberculization of the population may have been responsible for concurrent acquirement of reactivity to lepromin. 5- There were, however, disagreements in both directions. There were 9.5 per cent of the children who were negative to the second PPD but positive to lepromin (Mitsuda). In all but one of these the lepromin reactions were small. On the other hand, there were 16.2 per cent who were positive to the second strength PPD but negative to lepromin. In 63.6 per cent of 88 children showing this type of disagreement, the reaction to tuberculin was 2 + or larger. The only explanation of these disagreements which is in conformity with thhe tuberculization hypothesis is that in some persons the two types of response are dissociated. Certain individuals are apparently capable of developing tuberculoid lesions when acid-fast bacilli are injected into the skin but have either lost or never possessed hypersensitivity to tuberculin. In other cases, hypersensitivity is present but capacity to localize the bacilli in the skin by formation of a tubercle is absent...
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Coleções:
06-national
/
BR
Base de dados:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Sintomas Tuberculínicos
/
Hanseníase
Tipo de estudo:
Risk_factors_studies
Limite:
Child
Idioma:
En
Revista:
Int. j. lepr
Ano de publicação:
1955
Tipo de documento:
Article