A further note on inoculation of monkeys with human leprosy, aterial after splenectomy
Int. j. lepr
; 13(n.esp): 88-97, Dec. 1945.
Article
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1227274
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1"}]
ABSTRACT
A further report on inoculation work with splenectomized monkeys is made, and the difficulty in producing disseminated lesions in that animal is stressed. The apparent success of the first experiment, previously reported, has not been repeated. It is suggested that one of the reasons for the failure of development of leprosy in experimental animals is that resistance develops after multiple inoculations, as shown by the strngly positive lepromin reaction that developed in most of our animals which had had more than one inoculation. Some support to this hypothesis is given by the postmortem results in monkey 13, in which there was apparent dissemination of the leprosy bacilli inoculated, but it cannot be claimed that this animal developed leprosy. In two animals, both of which had been fed on colocasia, an acid-fast diphtheroid was found. In both of them erythematous lesions developed, and both showed signs of paralysis. Reasons for believing that the organism encountered was not M.leprae are given. No definite conclusion on this finding can be drawn because it was noted that an acid-fast bacillus, similar in morphology to that obtained from the erythematous lesion, can be demonstrated occasionally in the eyebrow of the normal monkey. The only definite inference that can be drawn from these experiments is that in monkey 1 of the previous series, and in monkey 13 of this series, there was evidence that the leprosy bacilli had become disseminated. There was, however, no evidence that progressive lesions had developed anf therefore none that leprosy was actually produced.
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Coleções:
06-national
/
BR
Base de dados:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Hanseníase
/
Mycobacterium leprae
Limite:
Animals
Idioma:
En
Revista:
Int. j. lepr
Ano de publicação:
1945
Tipo de documento:
Article