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Single lesion paucibacillary leprosy: baseline profile of the Brazilian Multicenter Cohort Study
Martelli, Celina M. T; Stefani, Mariane M. A; Gomes, Maria Katia; Rebello, Paula F. B; Peninni, Silmara; Narahashi, Kasue; Maroclo, Ana Lucia O; Costa, Mauricio B; Silva, Simonne A; Sacchetim, Sylvana C; Nery, Jose Augusto C; Salles, Ana Maria; Gillis, Thomas P; Krahenbuhl, James L; Andrade, Ana Lucia S. S.
Afiliação
  • Martelli, Celina M. T; Universidade Federal de Goias. Goiania. BR
  • Stefani, Mariane M. A; Universidade Federal de Goias. Goiania. BR
  • Gomes, Maria Katia; Universidade Federal do Rio de Janeiro. Hospital Clementino Fraga Filho. Rio de Janeiro. BR
  • Rebello, Paula F. B; WHO Leprosy Reference Center. Fundação Alfredo da Matta. Amazonas. BR
  • Peninni, Silmara; WHO Leprosy Reference Center. Fundação Alfredo da Matta. Amazonas. BR
  • Narahashi, Kasue; Secretaria da Saúde de Porto Velho. Porto Velho. BR
  • Maroclo, Ana Lucia O; Universidade Federal de Goias. Goiania. BR
  • Costa, Mauricio B; Universidade Federal de Goias. Goiania. BR
  • Silva, Simonne A; Universidade Federal de Goias. Goiania. BR
  • Sacchetim, Sylvana C; Universidade Federal de Goias. Goiania. BR
  • Nery, Jose Augusto C; Fundação Oswaldo Cruz. Laboratorio de Refêrencia em Hanseníase. Rio de Janeiro. BR
  • Salles, Ana Maria; Fundação Oswaldo Cruz. Laboratorio de Refêrencia em Hanseníase. Rio de Janeiro. BR
  • Gillis, Thomas P; GWL Hansen´s Disease Center at Louisiana State University. Laboratory Research Branch. Baton Rouge. US
  • Krahenbuhl, James L; GWL Hansen´s Disease Center at Louisiana State University. Laboratory Research Branch. Baton Rouge. US
  • Andrade, Ana Lucia S. S; Universidade Federal de Goias. Goiania. BR
Int. j. lepr. other mycobact. dis ; 68(3): 247-257, Sept., 2000. tab, graf, map
Article em En | SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP | ID: biblio-1226954
Biblioteca responsável: BR191.1
Localização: [{"text": "BR191.1"}]
ABSTRACT
In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the 299 SSL-PB leprosy patients, 259 (86.6%) fulfilled the criteria for single-dose ROM intervention. Our results showed that patients recruited from different sites had similar features, considering the clinical and immunological profiles. There was a predominance of adults (mean age 32.4; S.D. = 16.0), and a BCG scar was detected in 76.7% of the children ( or = 5 mm) and seropositivity for anti-PGL-I was detected in 17.3% of the patients. These data are compatible with effective cell-mediated immunity and low bacillary load, suggesting favorable clinical outcomes for most SSL-PB participants of this cohort.
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Texto completo: 1 Coleções: 06-national / BR Base de dados: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO Assunto principal: Hanseníase Dimorfa / Hanseníase Virchowiana / Hanseníase Tuberculoide / Hanseníase Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int. j. lepr. other mycobact. dis Ano de publicação: 2000 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 06-national / BR Base de dados: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO Assunto principal: Hanseníase Dimorfa / Hanseníase Virchowiana / Hanseníase Tuberculoide / Hanseníase Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int. j. lepr. other mycobact. dis Ano de publicação: 2000 Tipo de documento: Article