Activity of Combinations of Dapsone, Rifampin, Minocycline, Clarithomycin, and Sparfloxacin Against M leprae-Infected Mice
Int. j. lepr. other mycobact. dis
; 63(2): 259-264, 1995. tab
Article
em En
| SES-SP, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1226559
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1"}]
ABSTRACT
In these studies we evaluated the activity of low levels of five antimicrobials against Mycobacterium leprae-infected mice when administered singly and in all possible two- and three-drug combinations. Antibiotics studied were dapsone (D) 0.0001% in the diet, rifampin (R) 20 mg/kg by gavage once monthly, minocycline (M) 0.004% in the diet, clarithromycin (C) 0.001% in the diet, and sparfloxacin (S) 5 mg/kg by gavage five times weekly. Singly each agent was found bacteriostatic (D + R) or partially bactericidal (M, C, and S) but not fully bactericidal. All 10 two-drug regimens were found at least bacteriostatic, 2 being [quot ]partially bactericidal[quot ] and 4 being [quot ]fully bactericidal.[quot ] Of the 10 three-drug regimens, 9 were found [quot ]fully bactericidal[quot ] and the other [quot ]partially bactericidal.[quot ] We conclude that combinations of antibiotics active against M. leprae are generally additive in combination
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Rifampina
/
Hanseníase
/
Minociclina
Idioma:
En
Revista:
Int. j. lepr. other mycobact. dis
Ano de publicação:
1995
Tipo de documento:
Article