Simultaneous PAGE, immunoblotting, and immunohistochemical analysis of differentiation associated keratins in lesions of the oral mucosa

Itoiz, M E; Larcher, F; Lanfranchi, H E; Diaz, J; Klein-Szanto, A J; Conti, C J

Itoiz, M E; Larcher, F; Lanfranchi, H E; Diaz, J; Klein-Szanto, A J; Conti, C J.

Afiliação

Itoiz, M E; s.af
Larcher, F; s.af
Lanfranchi, H E; s.af
Diaz, J; s.af
Klein-Szanto, A J; s.af
Conti, C J; Departament of Pathology, Faculty of Dentistry, University of Buenos Aires, Argentina..

Acta odontol. latinoam ; Acta odontol. latinoam;7(2): 13-22, 1993.

Article em Es | LILACS-Express | LILACS, BINACIS | ID: biblio-1157677

Biblioteca responsável: AR29.1

Localização: [{"text": "AR29.1"}]

ABSTRACT

ABSTRACT

The expression of differentiation associated high PM Keratin polypeptides of the oral mucosa lesions were studied by immunohistochemical and immunoblotting techniques applied to adjacent sections of each biopsy specimen. The material studied included specimens of leukoplakia, verrucous carcinoma, squamous cell carcinoma, adenocarcinoma and keratoacanthoma. Little or no expression of 65-67 Kd keratins was evident in squamous cell carcinoma and adenocarcinoma. Hyperkeratotic (both benign and dysplastic) lesions such as verrucous carcinoma, leukoplakia, and keratoacanthoma, showed great variations in the intensity of 65-67 bands and a very irregular immunohistochemical staining pattern. Increased amounts of horny substance was usually accompanied by absence of, or decreased expression of 65-67 Kd keratins, thus indicating a change in the polypeptide composition of the horny layer in pathological conditions of the oral epithelium.

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Coleções: 01-internacional Base de dados: BINACIS / LILACS Tipo de estudo: Risk_factors_studies Idioma: Es Revista: Acta odontol. latinoam Assunto da revista: ODONTOLOGIA Ano de publicação: 1993 Tipo de documento: Article País de publicação: Argentina

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