Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019

Chun, Zeng Mei; Jun, Jia Qing

Chun, Zeng Mei; Jun, Jia Qing.

Afiliação

Chun, Zeng Mei; Zhejiang University. College of Medicine. The First Affiliated Hospital. Hangzhou. CN
Jun, Jia Qing; Hangzhou Center for Disease Control and Prevention. Department of TB Control and Prevention. Hangzhou. CN

Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;54: e0728-2020, 2021. tab, graf

Article em En | LILACS | ID: biblio-1155535

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

Abstract

INTRODUCTION:

Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.

METHODS:

MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.

RESULTS:

Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).

CONCLUSIONS:

The proportion of mono-SM-resistant TB among new patients was higher.

Related resources

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Assuntos

Humanos; Preparações Farmacêuticas; Tuberculose Resistente a Múltiplos Medicamentos; Mycobacterium tuberculosis/genética; Proteínas de Bactérias/genética; Testes de Sensibilidade Microbiana; China; Mutação; Antituberculosos/farmacologia

Palavras-chave

Drug resistance; Gene mutations; Gene sequencing; M. tuberculosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Preparações Farmacêuticas / Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Rev. Soc. Bras. Med. Trop Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

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