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Lipoprotein(a) levels in children and adolescents: Ouro Preto Study
Cândido, Ana Paula C; Mendonça-Mendes, Alekson; Cândido, Débora RC; Nicolato, Roney LC; Machado-Coelho, George LL.
Afiliação
  • Cândido, Ana Paula C; Universidade Federal de Juiz de Fora. Juiz de Fora. BR
  • Mendonça-Mendes, Alekson; Universidade Federal de Ouro Preto. Ouro Preto. BR
  • Cândido, Débora RC; Universidade Federal de Ouro Preto. Ouro Preto. BR
  • Nicolato, Roney LC; Universidade Federal de Ouro Preto. Ouro Preto. BR
  • Machado-Coelho, George LL; Universidade Federal de Ouro Preto. Ouro Preto. BR
Int. j. cardiovasc. sci. (Impr.) ; 34(1): 10-18, Jan.-Feb. 2021. tab
Article em En | LILACS | ID: biblio-1154531
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Background Lipoprotein (a) is a cardiovascular risk factor in adult. Studies have shown the presence of this emergent risk factor in school children, which may contribute to the development of atherosclerosis in adulthood. Objective To evaluate the association between lipoprotein (a) and cardiovascular risk factors in school children. Methods Lipoprotein (a) levels were measured in 320 school children (6-14 years) selected from a population survey carried out in Ouro Preto (southeast of Brazil). Demographic (sex and age), biochemical (total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, and glucose), anthropometric (body mass index, waist circumference, body fat percentage), clinical (arterial blood pressure, pubertal stage and birth weight) and economic (family income) parameters, as well as family history (obese and/or hypertensive parents) were analyzed. Non-parametric analysis was used to evaluate lipoprotein (a) levels in each subgroup. Variables with p≤0.20 in the univariate analysis were included in binary regression logistic model. Differences with p < 0.05 were considered significant. Results Lipoprotein (a) levels were associated with total cholesterol (p=0.04), body fat (p=0.009), and mother´s systolic (p=0.02) and diastolic blood pressure (p=0.04). In a logistic regression analysis, children with high lipoprotein (a) levels and body fat, and children born from hypertensive mothers were, respectively, at 3.2(p=0.01) and 1.4 (p=0.03) times higher risk than other children. In clustering these factors, elevated lipoprotein (a) was 2.6 times more likely to be seen in school children with high body fat and born hypertensive mothers. Conclusions Lipoprotein (a) was correlated with cardiovascular risk factors in children and adolescents. Persistence of these risk factors in childhood suggests a contribution of elevated lipoprotein (a) to future cardiovascular disease. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças Cardiovasculares / Lipoproteína(a) / Fatores de Risco de Doenças Cardíacas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Assunto da revista: CARDIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças Cardiovasculares / Lipoproteína(a) / Fatores de Risco de Doenças Cardíacas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Int. j. cardiovasc. sci. (Impr.) Assunto da revista: CARDIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil