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Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis
Crescente, Juliana Goldbaum; Dellavance, Alessandra; Diniz, Marcio Augusto; Carrilho, Flair Jose; Andrade, Luis Eduardo Coelho de; Cançado, Eduardo Luiz Rachid.
Afiliação
  • Crescente, Juliana Goldbaum; Departamento de Gastroenterologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo. Sao Paulo. BR
  • Dellavance, Alessandra; Disciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo. Sao Paulo. BR
  • Diniz, Marcio Augusto; Cedars Sinai Medical Center. Samuel Oschin Comprehensive Cancer Institute. Biostatistics and Bioinformatics Research Center. Los Angeles. US
  • Carrilho, Flair Jose; Departamento de Gastroenterologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo. Sao Paulo. BR
  • Andrade, Luis Eduardo Coelho de; Disciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo. Sao Paulo. BR
  • Cançado, Eduardo Luiz Rachid; Departamento de Gastroenterologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo. Sao Paulo. BR
Clinics ; Clinics;76: e2228, 2021. tab
Article em En | LILACS | ID: biblio-1153999
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

To determine the frequency of the antineutrophil cytoplasmic antibodies (ANCA), antiproteinase-3 and antimyeloperoxidase, in primary sclerosing cholangitis (PSC) with or without inflammatory bowel disease (IBD+ or IBD-) and in different types of autoimmune hepatitis (AIH). Additionally, to verify the agreement between ANCA patterns by indirect immunofluorescence and their antigenic specificities by ELISA.

METHODS:

For this study, 249 patients were enrolled (42 PSC/IBD+; 33 PSC/IBD-; 31 AIH type-1; 30 AIH type-2; 31 AIH type-3; 52 primary biliary cirrhosis; 30 healthy controls) whose serum samples were tested for ANCA autoantibodies.

RESULTS:

There were fewer female subjects in the PSC/IBD- group (p=0.034). Atypical perinuclear-ANCA was detected more frequently in PSC/IBD+ patients than in PSC/IBD- patients (p=0.005), and was significantly more frequent in type-1 (p<0.001) and type-3 AIH (p=0.012) than in type-2 AIH. Proteinase-3-ANCA was detected in 25 samples (only one with cytoplasmic-ANCA pattern), and more frequently in PSC/IBD+ than in PSC/IBD- patients (p=0.025). Myeloperoxidase-ANCA was identified in eight samples (none with the perinuclear-ANCA pattern). Among the 62 reactive samples for atypical perinuclear-ANCA, 13 had antigenic specific reactions for proteinase-3 and myeloperoxidase.

CONCLUSIONS:

PSC/IBD+ differed from PSC/IBD- in terms of sex and proteinase 3-ANCA and atypical perinuclear-ANCA reactivity, the latter of which was more frequently detected in type-1 and type-3 AIH than in type-2 AIH. There was no agreement between ANCA patterns and antigenic specificities in IBD and autoimmune liver diseases, which reinforces the need for proteinase-3 and myeloperoxidase antibody testing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Colangite Esclerosante / Hepatite Autoimune Limite: Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil / Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Colangite Esclerosante / Hepatite Autoimune Limite: Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil / Estados Unidos País de publicação: Brasil