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Transcriptomic markers in pediatric septic shock prognosis: an integrative analysis of gene expression profiles
Wang, Qian; Huang, Jie; Chen, Xia; Wang, Jian; Fang, Fang.
Afiliação
  • Wang, Qian; Childrens Hospital of Soochow University. Anesthesiology Department. CN
  • Huang, Jie; Childrens Hospital of Soochow University. Department of Cardiology. CN
  • Chen, Xia; Childrens Hospital of Soochow University. Anesthesiology Department. CN
  • Wang, Jian; Institute of Pediatric Research, Childrens Hospital of Soochow University. CN
  • Fang, Fang; Institute of Pediatric Research, Childrens Hospital of Soochow University. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;54(3): e10152, 2021. tab, graf
Article em En | LILACS | ID: biblio-1153522
Biblioteca responsável: BR1.1
ABSTRACT
The goal of this study was to identify potential transcriptomic markers in pediatric septic shock prognosis by an integrative analysis of multiple public microarray datasets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in pediatric septic shock non-survivors, and further performed functional interpretation (enrichment analysis and co-expression network construction) and classification quality evaluation of the DE genes identified. Four microarray datasets (3 training datasets and 1 testing dataset, 252 pediatric patients with septic shock in total) were collected for the integrative analysis. A total of 32 DE genes (18 upregulated genes; 14 downregulated genes) were identified in pediatric septic shock non-survivors. Enrichment analysis revealed that those DE genes were strongly associated with acute inflammatory response to antigenic stimulus, response to yeast, and defense response to bacterium. A support vector machine classifier (non-survivors vs survivors) was also trained based on DE genes. In conclusion, the DE genes identified in this study are suggested as candidate transcriptomic markers for pediatric septic shock prognosis and provide novel insights into the progression of pediatric septic shock.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Choque Séptico / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Choque Séptico / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Child / Humans Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Brasil