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Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles
Klemm, Philipp; Becker, Johanna; Aykara, Iris; Asendorf, Thomas; Dischereit, Gabriel; Neumann, Elena; Müller-Ladner, Ulf; Lange, Uwe.
Afiliação
  • Klemm, Philipp; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Becker, Johanna; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Aykara, Iris; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Asendorf, Thomas; University Medical Center Gottingen. Department of Medical Statistics. Göttingen. DE
  • Dischereit, Gabriel; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Neumann, Elena; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Müller-Ladner, Ulf; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
  • Lange, Uwe; Justus-Liebig-University Giessen. Department of Rheumatology, Osteology and Physical Medicine. Bad Nauheim. DE
Adv Rheumatol ; 61: 3, 2021. tab, graf
Article em En | LILACS | ID: biblio-1152737
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Introduction:

Whole-body cryotherapy (WBC) has shown to be beneficial in the treatment of fibromyalgia (FM). There is cumulative evidence that cytokines play a crucial role in FM. It's unknown whether clinical effects of WBC can be demonstrated at the molecular level and how long the effects last.

Methods:

We compared effects of serial WBC (6 sessions (- 130 °C in 6 weeks) in FM patients and healthy controls (HC). Primary outcome was the change in pain level (visual analogue scale 0-100 mm) after 6 sessions. Secondary outcomes were a change in disease activity (revised Fibromyalgia Impact Questionnaire) and pain after 3 sessions and 3 months after discontinued therapy and in cytokine levels (interleukin (IL-)1, IL-6, tumor necrosis factor α (TNF-α) and IL-10). The patients' opinions on the satisfaction, effectiveness and significance of WBC were evaluated.

Results:

Twenty-three FM patients and 30 HC were enrolled. WBC resulted in a significant reduction in pain and disease activity after 3 and 6 sessions. No clinical benefit could be measured 3 months after discontinued treatment. Overall, probands were satisfied with WBC and considered WBC to be important and effective. FM patients had significantly different levels of IL-1, IL-6, TNF-α and IL-10 at each reading point compared to HC. Levels of IL-1, IL-6 and IL-10 were significantly altered over time in FM patients. Compared to HC FM patients showed a significantly different response of IL1, - 6 and - 10 to WBC.

Conclusion:

Serial WBC is a fast acting and effective treatment for FM. Proven effects of WBC may be explained by changes in cytokines.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Fibromialgia / Citocinas / Crioterapia Limite: Humans Idioma: En Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Fibromialgia / Citocinas / Crioterapia Limite: Humans Idioma: En Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Brasil