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Global prevalence of protein-energy wasting in kidney disease: A meta-analysis of contemporary observational studies from the international society of renal nutrition and metabolism
Pharm, Juan J Carrero; Biostat, Fridtjof Thomas; Nagy, Kristof; Arogundade, Fatiu; Avesani, Carla M; Chan, Maria; Chmielewski, Michal; Cordeiro, Antonio C; Espinosa-Cuevas, Angeles; Fiaccadori, Enrico; Guebre-Egziabher, Fitsum; Hand, Rosa K; Hung, Adriana M; Ikizler, Talat A; Johansson, Lina R; Kalantar-Zadeh, Kamyar; Karupaiah, Tilakavati; Lindholm, Bengt; Marckmann, Peter; Mafra, Denise; Parekh, Rulan S; Park, Jongha; Russo, Sharon; Saxena, Anita; Sezer, Siren; Teta, Daniel; Ter Wee, Pieter M; Wang, Angela Y M; Xu, Hong; Lu, Yimin; Molnar, Miklos Z; Kovesdy, Csaba P.
Afiliação
  • Pharm, Juan J Carrero; Karolinska Institutet. Department of Medical Epidemiology and Biostatistics. Department of Clinical Science, Intervention and Technology. Estocolmo. SE
  • Biostat, Fridtjof Thomas; University of Tennessee Health Science Center. Department of Internal Medicine. Division of Biostatistics (FT), Department of Preventive Medicine, and Division of Nephrology. Tennessee. US
  • Nagy, Kristof; Semmelweis University. Department of Transplantation and Surgery. Budapest. US
  • Arogundade, Fatiu; Obafemi Awolowo University. NE
  • Avesani, Carla M; Nutrition Institute, State University Rio de Janeiro. Karolinska Institutet. Department of Medical Epidemiology and Biostatistics, Department of Clinical Science, Intervention and Technology. Rio de Janeiro. BR
  • Chan, Maria; Department of Nutrition and Dietetics, The St. George Hospital. Kogarah. AU
  • Chmielewski, Michal; Medical University of Gdansk. Department of Nephrology, Transplantology and Internal Medicine. Gdansk. PL
  • Cordeiro, Antonio C; Dante Pazzanese Institute of Cardiology. Department of Hypertension and Nephrology. São Paulo. BR
  • Espinosa-Cuevas, Angeles; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Nephrology and Mineral Metabolism Department. Salvador Zubiran. MX
  • Fiaccadori, Enrico; University of Parma. Division of Nephrology, Department of Medicine and Surgery. Parma. IT
  • Guebre-Egziabher, Fitsum; Claude Bernard University Lyon 1. Department of Nephrology, Dialysis, Hypertension, Hôpital Edouard Herriot, Hospices Civils de Lyon. Lyon. FR
  • Hand, Rosa K; University of Ulsan College of Medicine. Division of Nephrology. Ulsan. KR
  • Hung, Adriana M; Department of Medicine, Division of Nephrology and Hypertension and Vanderbilt Center for Kidney Diseases Vanderbilt University ,Medical Center. Veterans Administration Tennessee Valley Healthcare System. Nashville. US
  • Ikizler, Talat A; Department of Medicine, Division of Nephrology and Hypertension and Vanderbilt Center for Kidney Diseases Vanderbilt University, Medical Center. Veterans, Administration Tennessee Valley, Healthcare System. Nashville. US
  • Johansson, Lina R; Department of Nutrition and Dietetics, Imperial College Healthcare NHS Trust. London. GB
  • Kalantar-Zadeh, Kamyar; University of California, Irvine, School of Medicine. Division of Nephrology and Hypertension. California. US
  • Karupaiah, Tilakavati; School of Biosciences, Faculty of Health & Medical Science, Taylor's University Lakeside Campus. Selangor. MY
  • Lindholm, Bengt; Karolinska Institutet. Department of Medical Epidemiology and Biostatistics, Department of Clinical Science, Intervention and Technology. Estocolmo. SE
  • Marckmann, Peter; Sjællands University Hospital. Roskilde. DK
  • Mafra, Denise; Fluminense Federal University. Graduate Program in Medical Sciences and Graduate Program in Cardiovascular Sciences. Niteroi. BR
  • Parekh, Rulan S; University of Toronto. Division of Nephrology, Departments of Pediatrics and Medicine, Hospital for Sick Children, University Health Network. Toronto. CA
  • Park, Jongha; Case Western Reserve University Department of Nutrition. Cleveland. US
  • Russo, Sharon; University Health Network and University of Toronto. Division of Nephrology, Departments of Pediatrics and Medicine, Hospital for Sick Children. Toronto. CA
  • Saxena, Anita; Department of Nephrology, Sanjay Gandhi Post Graduate, Institute of Medical Sciences. Lucknow. IN
  • Sezer, Siren; Baskent University Faculty of Medicine. Ankara. TR
  • Teta, Daniel; Service of Nephrology, Hospital of Sion, University of Lausanne. Lausanne. CH
  • Ter Wee, Pieter M; Department of Nephrology VUmc, ICaR-VU. Amsterdam. NL
  • Wang, Angela Y M; Department of Medicine, University of Hong Kong, Queen Mary Hospital. Hong Kong. JP
  • Xu, Hong; Karolinska Institutet. Department of Medical Epidemiology and Biostatistics, Department of Clinical Science, Intervention and Technology. Estocolmo. SE
  • Lu, Yimin; Service of Nephrology, Hospital of Sion, University of Lausanne. Lausanne. CH
  • Molnar, Miklos Z; University of Tennessee Health Science Center. Division of Biostatistics (FT), Department of Preventive Medicine, and Division of Nephrology, Department of Internal Medicine. Tennessee. US
  • Kovesdy, Csaba P; Division of Biostatistics (FT), Department of Preventive Medicine, and Division of Nephrology, Department of Internal Medicine, University of Tennessee Health Science Center. Tennessee. US
J. renal nutr ; 28(6): 380-392, Nov. 2018. graf, ilus, tab
Article em En | CONASS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1152273
Biblioteca responsável: BR79.1
ABSTRACT

Objective:

To better define the prevalence of protein-energy wasting (PEW) in kidney disease is poorly defined.

Methods:

We performed a meta-analysis of PEW prevalence from contemporary studies including more than 50 subjects with kidney disease, published during 2000-2014 and reporting on PEW prevalence by subjective global assessment or malnutrition-inflammation score. Data were reviewed throughout different strata (1) acute kidney injury (AKI), (2) pediatric chronic kidney disease (CKD), (3) nondialyzed CKD 3-5, (4) maintenance dialysis, and (5) subjects undergoing kidney transplantation (Tx). Sample size, period of publication, reporting quality, methods, dialysis technique, country, geographical region, and gross national income were a priori considered factors influencing between-study variability.

Results:

Two studies including 189 AKI patients reported a PEW prevalence of 60% and 82%. Five studies including 1776 patients with CKD stages 3-5 reported PEW prevalence ranging from 11% to 54%. Finally, 90 studies from 34 countries including 16,434 patients on maintenance dialysis were identified. The 25th-75th percentiles range in PEW prevalence among dialysis studies was 28-54%. Large variation in PEW prevalence across studies remained even when accounting for moderators. Mixed-effects meta-regression identified geographical region as the only significant moderator explaining 23% of the observed data heterogeneity. Finally, two studies including 1067 Tx patients reported a PEW prevalence of 28% and 52%, and no studies recruiting pediatric CKD patients were identified.

Conclusion:

By providing evidence-based ranges of PEW prevalence, we conclude that PEW is a common phenomenon across the spectrum of AKI and CKD. This, together with the well-documented impact of PEW on patient outcomes, justifies the need for increased medical attention.
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Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Prevalência / Insuficiência Renal Crônica / Ciências da Nutrição / Metabolismo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J. renal nutr Ano de publicação: 2018 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
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Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Prevalência / Insuficiência Renal Crônica / Ciências da Nutrição / Metabolismo Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: J. renal nutr Ano de publicação: 2018 Tipo de documento: Article