Rapid responses to golimumab in refractory adult-onset Stills disease: A case report and review of the literature
Rev. colomb. reumatol
; 26(4): 271-275, oct.-dic. 2019. graf
Article
em En
| LILACS
| ID: biblio-1138820
Biblioteca responsável:
CO356.9
ABSTRACT
ABSTRACT Introduction:
Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology. AOSD is generally a mild and self-limiting disease, but it could progress to become chronic. The anemia of chronic diseases may occur in patients with acute or chronic immune activation, and is associated with the production of pro-inflammatory cytokines. Case report A 61-year-old woman with several pharyngitis episodes, spiking fever, evanescent salmon-pink skin rash, normocytic normochromic anemia, leucocytosis, thrombocytopenia, polyarthritis, liver dysfunction, marked elevated erythrocyte sedimentation rate and C-reactive protein and, notably high ferritin levels. AOSD was diagnosed after secondary diseases were ruled out. Despite eight month on treatment with high-dose corticosteroids and methotrexate the clinical course the patient worsened, with significant synovitis, joint deformities leading to a worse quality of life and requiring help with activities of daily living. A rapid response to the anti-TNFα golimumab (50 mg/month) was observed from the third month of treatment.Conclusion:
Golimumab improved anemia, serum C-reactive protein levels, polyarthritis and quality of life in a refractory AOSD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Citocinas
/
Doença de Still de Início Tardio
Aspecto:
Patient_preference
Limite:
Female
/
Humans
Idioma:
En
Revista:
Rev. colomb. reumatol
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
Colômbia