Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;53: e20190404, 2020. tab, graf
Article
em En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136910
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.METHODS:
Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing.RESULTS:
The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households.CONCLUSIONS:
Drug-resistant tuberculosis was relatively low and transmitted in households and the community.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
SES-SP
/
ColecionaSUS
Assunto principal:
Polimorfismo de Fragmento de Restrição
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Brasil
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Prevalência
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Estudos Transversais
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Tuberculose Resistente a Múltiplos Medicamentos
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Terapia Diretamente Observada
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Mycobacterium tuberculosis
Tipo de estudo:
Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil