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A retrospective cohort study to screen linezolid-induced thrombocytopenia in adult patients hospitalized in the Midwestern Region of Brazil
Lima, Letícia Souza; Brito, Eliana da Costa Alvarenga; Mattos, Karine; Parisotto, Eduardo Benedetti; Perdomo, Renata Trentin; Weber, Simone Schneider.
Afiliação
  • Lima, Letícia Souza; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
  • Brito, Eliana da Costa Alvarenga; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
  • Mattos, Karine; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
  • Parisotto, Eduardo Benedetti; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
  • Perdomo, Renata Trentin; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
  • Weber, Simone Schneider; Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 42(3): 230-237, July-Sept. 2020. tab, graf, ilus
Article em En | LILACS | ID: biblio-1134032
Biblioteca responsável: BR408.1
Localização: BR408.1
ABSTRACT
ABSTRACT

Background:

Thrombocytopenia (TP) is the major event associated with linezolid (LZD) therapy. We investigated the incidence and risk factors for thrombocytopenia in hospitalized adults who received LZD (1200 mg/day) between 2015 and 2017. HIV-positive, death during follow-up and those with a baseline platelet count ≤100 × 103/mm3 were excluded.

Method:

TP was defined as a decrease in platelet count of ≥20% from the baseline level at the initiation of linezolid therapy and a final count of <100 × 103/mm3. The odds ratios (OR) for thrombocytopenia were obtained using multivariate stepwise logistic regression analysis. Main

results:

A total of 66 patients were included (mean age [SD] 62 [18], male gender [%], 37 [56]). LZD-associated TP was identified in 12 patients (18.2%). For TP, the adjusted OR [95% CI] of the platelet count ≤200 × 103/mm3, serum creatinine and renal impairment at baseline were 5.66 [1.15-27.9], 4.57 [1.26-16.5] and 9.41 [1.09-80.54], respectively. Male gender and dosage per weight per day (DPWD) >20 mg/kg/day were not risk factors.

Conclusion:

The results showed that the incidence of linezolid-induced thrombocytopenia was lower in patients with normal renal function and higher in those with platelet counts ≤200 × 103/mm3 or serum creatinine >1.5 mg/dL at the start of the treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Trombocitopenia / Creatinina / Insuficiência Renal / Linezolida Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Trombocitopenia / Creatinina / Insuficiência Renal / Linezolida Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Hematol., Transfus. Cell Ther. (Impr.) Assunto da revista: Hematologia / TransfusÆo de Sangue Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil