Immunostaining study of cytokeratins in human hair follicle development
An. bras. dermatol
; An. bras. dermatol;95(3): 278-282, May-June 2020. tab, graf
Article
em En
| LILACS, ColecionaSUS
| ID: biblio-1130884
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
The hair follicle is a unique structure, one of the most dynamic structures in mammalians, which can reproduce in every new cycle all the mechanism involved in its fetal development. Although a lot of research has been made about the human hair follicle much less has been discovered about the importance of the cytokeratins (CKs) in its development.Objective:
Study the immunohistochemical pattern of epithelial CKs during human hair follicle development.Methods:
We performed an immunohistochemical study using fresh post-mortem skin biopsies of human fetuses between 4 and 25 weeks of gestational age to study the expression of cytokeratins (CKs) CK1, CK10, CK13, CK14, CK16 and CK20 during human hair follicle fetal development. Studylimitations:
Restrospective study with a good number of makers but with a small population. Results/conclusion:
We found that, the CKs were expressed in an intermediate time during follicular development. The epithelial CKs (CK1, CK14, CK10, CK13) and the epithelial CKs with a proliferative character such as CK16 were expressed first, as markers of cellular maturation and follicular keratinization. At a later phase, CK20 was expressed in more developed primitive hair follicles as previously discussed in literature.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
ColecionaSUS
Assunto principal:
Folículo Piloso
/
Queratinas Específicas do Cabelo
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil