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Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats
Azevedo, Ítalo Medeiros; Macedo Filho, Robson; Rocha, Keyla Borges Ferreira; Oliveira, Cláudia Nunes; Medeiros, Aldo Cunha.
Afiliação
  • Azevedo, Ítalo Medeiros; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Macedo Filho, Robson; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Rocha, Keyla Borges Ferreira; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Oliveira, Cláudia Nunes; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Medeiros, Aldo Cunha; UFRN. Nucleus of Experimental Surgery. Natal. BR
Acta cir. bras ; Acta cir. bras;35(5): e202000505, 2020. tab, graf
Article em En | LILACS | ID: biblio-1130643
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Purpose The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats. Methods Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours. Results All animals survived for postoperative 24h. The abdomen/liver ratio of the standardized uptake value (SUV) percentage was significantly higher in the sepsis group than in the sham (p=0.004). The ROC curve showed an accuracy of 18F-FDG-PET to detect abdominal sepsis of 88.9% (p=0.001), sensitivity of 90% and specificity of 88.9%. When a cut-off point of 79% of the ratio between the SUV on the abdominal region and liver was established, the sensitivity was 90%, specificity of 88.9%; positive and negative predictive values of 90.0% and 88.9%, respectively. Conclusions The diagnostic accuracy of 18F-FDG-PET in rats with abdominal sepsis was significantly high. It was also demonstrated the predictive ability of the abdomen/liver SUV ratio to diagnose abdominal sepsis. These findings may have implications for the clinical setting, locating septic foci with PETscan.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Sepse / Compostos Radiofarmacêuticos / Fluordesoxiglucose F18 / Tomografia por Emissão de Pósitrons / Infecções Intra-Abdominais Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Sepse / Compostos Radiofarmacêuticos / Fluordesoxiglucose F18 / Tomografia por Emissão de Pósitrons / Infecções Intra-Abdominais Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil