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Evaluation of the association between KIR polymorphisms and systemic sclerosis: a meta-analysis
Karimizadeh, Elham; Mostafaei, Shayan; Aslani, Saeed; Gharibdoost, Farhad; Xavier, Ricardo Machado; Salim, Patricia Hartstein; Kavosi, Hoda; Farhadi, Elham; Mahmoudi, Mahdi.
Afiliação
  • Karimizadeh, Elham; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
  • Mostafaei, Shayan; Kermanshah University of Medical Sciences. Health Technology Institute. Medical Biology Research Center. Kermanshah. IR
  • Aslani, Saeed; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
  • Gharibdoost, Farhad; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
  • Xavier, Ricardo Machado; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre. BR
  • Salim, Patricia Hartstein; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Serviço de Reumatologia. Porto Alegre. BR
  • Kavosi, Hoda; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
  • Farhadi, Elham; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
  • Mahmoudi, Mahdi; Tehran University of Medical Sciences. Shariati Hospital. Rheumatology Research Center. Tehran. IR
Adv Rheumatol ; 60: 08, 2020. tab, graf
Article em En | LILACS | ID: biblio-1088648
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed.

Methods:

A systematic literature search was performed in electronic databases including Scopus and PubMed/ MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk.

Results:

Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc.

Conclusions:

The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Escleroderma Sistêmico Tipo de estudo: Etiology_studies / Evaluation_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil / Irã País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polimorfismo Genético / Escleroderma Sistêmico Tipo de estudo: Etiology_studies / Evaluation_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil / Irã País de publicação: Brasil