Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine
Trans.Royal Trop.Med.Hyg
; 91: 697-700, may.-1997. tab, graf
Article
em En
| SES-SP, SESSP-SUCENPROD, SES-SP
| ID: biblio-1068298
Biblioteca responsável:
BR93.2
Localização: BR93.2
ABSTRACT
Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50 = 44.26 and 46.53 ug/L for desipramine L for imipramine), but no reversal of resistance when added to cultures together with chloroquine.
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-SUCENPROD
Assunto principal:
Plasmodium falciparum
/
Cloroquina
/
Desipramina
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Trans.Royal Trop.Med.Hyg
Ano de publicação:
1997
Tipo de documento:
Article