Regional brain c-fos activation associated with penile erection and other symptoms induced by the spider toxin Tx2-6
Toxicon
; Toxicon;58(2): 202-208, 2011.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1068281
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Brain areas expressing c-fos messenger RNA were mapped by quantitative in situhybridization after 12 h of intoxication with 10 mg/kg Tx2-6, a toxin obtained from the venom of the spider Phoneutria nigriventer. Relative to saline-treated controls, brains from toxin-treated animals showed pronounced c-fos activation in many brain areas, includingthe supraoptic nucleus, the paraventricular nucleus of the hypothalamus, the motor nucleus of the vagus, area postrema, paraventricular and paratenial nuclei of the thalamus,locus coeruleus, central amydaloid nucleus and the bed nucleus of the stria terminalis. The paraventricular hypothalamus and the bed nucleus of the stria terminalis have been implicated in erectile function in other studies. A possible role for central NO is considered. Acute stress also activates many brain areas activated by Tx2-6 as well as with NO stimulated Fos transcription. Brain areas that appear to be selectively activated by Tx2-6, include the paratenial and paraventricular thalamic nuclei, the bed nucleus of the stria terminalis and the area postrema and the dorsal motor n. of vagus in the medulla. However, direct injections of different doses of the toxin into the paraventricular hypothalamicn. failed to induce penile erection, arguing against CNS involvement in thisparticular effect.
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Coleções:
06-national
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BR
Base de dados:
SES-SP
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SESSP-IBACERVO
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SESSP-IBPROD
Assunto principal:
Aranhas
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Ereção Peniana
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Neurotoxinas
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
2011
Tipo de documento:
Article