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A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system
Tavassi, Ana Marisa Chudzinski; Júnior, Paulo Luis De Sá; Simons, Simone Michaela; Maria, Durvanei Augusto; Ventura, Janaina de Souza; Batista, Isabel de Fátima Correia; Faria, Fernanda; Durães, Esther; Reis, Eduardo Moraes; Demasi, Marilene.
Afiliação
  • Tavassi, Ana Marisa Chudzinski; Instituto Butantan. São Paulo. BR
  • Júnior, Paulo Luis De Sá; Instituto Butantan. São Paulo. BR
  • Simons, Simone Michaela; Instituto Butantan. São Paulo. BR
  • Maria, Durvanei Augusto; Instituto Butantan. São Paulo. BR
  • Ventura, Janaina de Souza; Instituto Butantan. São Paulo. BR
  • Batista, Isabel de Fátima Correia; Instituto Butantan. São Paulo. BR
  • Faria, Fernanda; Instituto Butantan. São Paulo. BR
  • Durães, Esther; s.af
  • Reis, Eduardo Moraes; s.af
  • Demasi, Marilene; Instituto Butantan. São Paulo. BR
Toxicon ; Toxicon;56(7)2010.
Article em En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1068261
Biblioteca responsável: BR78.1
Localização: BR78.1
ABSTRACT
The aim of this study was to evaluate the anti-tumor activity of Amblyomin-X, a serine protease Kunitz-type inhibitor. Amblyomin-X induced tumor mass regression and decreased number of metastatic events in a B16F10 murine melanoma model. Alterations on expression of several genes related to cell cycle were observed when two tumor cell lines were treated with Amblyomin-X. PSMB2, which encodes a proteasome subunit, was differentially expressed, in agreement to inhibition of proteasomal activity in both cell lines. In conclusion, our results indicate that Amblyomin-X selectively acts on tumor cells by inducing apoptotic cell death, possibly by targeting the ubiquitin-proteasome system.
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Carrapatos / Aprotinina Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2010 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Carrapatos / Aprotinina Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2010 Tipo de documento: Article