Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization
PloS neglected tropical diseases
; 4(3): 1-12, 2010.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1065511
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Micrurus snake bites can cause death by muscle paralysis and respiratory arrest, few hours after envenomation.The specific treatment for coral snake envenomation is the intravenous application of heterologous antivenom and, inBrazil, it is produced by horse immunization with a mixture of M. corallinus and M. frontalis venoms, snakes that inhabit theSouth and Southeastern regions of the country. However, this antivenom might be inefficient, considering the existence ofintra- and inter-specific variations in the composition of the venoms. Therefore, the aim of the present study was toinvestigate the toxic properties of venoms from nine species of Micrurus eight present in different geographic regions ofBrazil (M. frontalis, M. corallinus, M. hemprichii, M. spixii, M. altirostris, M. surinamensis, M. ibiboboca, M. lemniscatus) and one(M. fulvius) with large distribution in Southeastern United States and Mexico. This study also analyzed the antigenic crossreactivityand the neutralizing potential of the Brazilian coral snake antivenom against these Micrurus venoms
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Elapidae
/
Venenos Elapídicos
/
Antídotos
Limite:
Animals
Idioma:
En
Revista:
PloS neglected tropical diseases
Ano de publicação:
2010
Tipo de documento:
Article