Your browser doesn't support javascript.
loading
Isolation and characterization of a novel bradykinin potentiating peptide (BPP) from the skin secretion of Phyllomedusa hypochondrialis
Conceição, Katia; Konno, Katsuhiro; Melo, Robson Lopes de; Antoniazzi, Marta M; Jared, Carlos; Sciani, Juliana M; Conceição, Isaltino M; Prezoto, Benedito C; Camargo, Antonio Carlos Martins de; Pimenta, Daniel C.
Afiliação
  • Conceição, Katia; Instituto Butantan. São Paulo. BR
  • Konno, Katsuhiro; Instituto Butantan. São Paulo. BR
  • Melo, Robson Lopes de; Instituto Butantan. São Paulo. BR
  • Antoniazzi, Marta M; Instituto Butantan. São Paulo. BR
  • Jared, Carlos; Instituto Butantan. São Paulo. BR
  • Sciani, Juliana M; Instituto Butantan. São Paulo. BR
  • Conceição, Isaltino M; Instituto Butantan. São Paulo. BR
  • Prezoto, Benedito C; Instituto Butantan. São Paulo. BR
  • Camargo, Antonio Carlos Martins de; Instituto Butantan. São Paulo. BR
  • Pimenta, Daniel C; Instituto Butantan. São Paulo. BR
Peptides ; Peptides;28(3): 515-523, 2007.
Article em En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1065273
Biblioteca responsável: BR78.1
Localização: BR78.1
ABSTRACT
Bradykinin potentiating peptides (BPPs) from Bothrops jararaca venom were first described in the middle of 1960s and were the first natural inhibitors of the angiotensin-converting enzyme (ACE). BPPs present a classical motif and can be recognized by their typical pyroglutamyl (Pyr)/proline rich sequences presenting, invariably, a proline residue at the C-terminus. In the present study, we describe the isolation and biological characterization of a novel BPP isolated from the skin secretion of the Brazilian tree-frog Phyllomedusa hypochondrialis. This new BPP, named Phypo Xa presents the sequence Pyr-Phe-Arg-Pro-Ser-Tyr-Gln-Ile-Pro-Pro and is able to potentiate bradykinin activities in vivo and in vitro, as well as efficiently and competitively inhibit ACE. This is the first canonical BPP (i.e. Pyr-Aaan-Gln-Ile-Pro-Pro) to be found not only in the frog skin but also in any other natural source other than the snake venoms.
Assuntos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Venenos de Serpentes / Serpentes / Anfíbios / Venenos de Anfíbios Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Venenos de Serpentes / Serpentes / Anfíbios / Venenos de Anfíbios Limite: Animals Idioma: En Revista: Peptides Ano de publicação: 2007 Tipo de documento: Article