Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response
Mem. Inst. Oswaldo Cruz
; 108(6): 796-800, set. 2013. tab, graf
Article
em En
| SES-SP, SESSP-SUCENPROD, SES-SP
| ID: biblio-1064722
Biblioteca responsável:
BR93.2
Localização: BR93.2
ABSTRACT
Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum, the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax (PvMSP1-19) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to on going parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-19 may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax...
Palavras-chave
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-SUCENPROD
Assunto principal:
Glicosilfosfatidilinositóis
/
Malária
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2013
Tipo de documento:
Article