Pleiotropic Effects With Equivalent Low-density Lipoprotein Cholesterol Reduction: Comparative StudyBetween Simvastatin and Simvastatin/Ezetimibe Coadministration
J Cardiovasc Pharmacol
; 55: 1-5, 2010.
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1063651
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Background:
Coadministration of any statin with ezetimibe is as effective as using high doses of the same statin in the reduction of low-density lipoprotein cholesterol (LDL-c). There may be othereffects called pleiotropics.Objective:
To compare the effectiveness of 2 different treatments that obtain equivalent LDL-c reductions (80 mg of simvastatin, oncea day and coadministration of 10 mg of simvastatin and 10 mg of ezetimibe, once a day) over endothelial function and inflammation.Methods:
Twenty-three randomized patients with hypercholesterolemia in a 2 3 2 crossover protocol were studied. Endothelial function was analyzed by ultrasound assessment of endothelialdependent flow-mediated vasodilation of the brachial artery, andinflammation was estimated by high-sensitivity C-reactive protein(hs-CRP).Results:
LDL-c reduction was similar between the 2 treatments withsimvastatin/ezetimibe and with simvastatin (P , 0.001); no differencebetween treatments was found (P = 0.968). Both treatments improved significantly the endothelial function [3.61% with simvastatin/ ezetimibe (P = 0.003) and 5.08% with simvastatin (P , 0.001)]; no difference was found between the 2 treatments (P = 0.291). hs-CRP had a 23% reduction with simvastatin/ezetimibe (P = 0.004) and a 30% reduction with simvastatin alone (P = 0.01), with no significant difference between the 2 treatments (P = 0.380).Conclusion:
The 2 forms of treatment presented similar pleiotropiceffects improvement in endothelial function and decrease in hs-CRP levels.
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IDPCPROD
Assunto principal:
Proteína C-Reativa
/
Hipercolesterolemia
Tipo de estudo:
Clinical_trials
/
Guideline
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Ano de publicação:
2010
Tipo de documento:
Article