Gabaergic influences on barbital withdrawal induced convulsions
General Pharmacology Vascular System
; 17(4): 431-435, 1986.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1063070
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Animals which had been long-term treated with increasing concentrations of sodium barbitalin the drinking water were killed 30 min or 72 hr after the last day of treatment, to determine striatalGABA levels and turnover rate. The effects of pentobarbital administration on GABA metabolism of rats withdrawn or notwithdrawn from barbital were also studied. Barbital withdrawal induced a significant decrease in striatal GABA levels and also in the turnoverrate after pentobarbital treatment.The latter effect was greater in rats killed 72 hr after drug removal. In control animals, pentobarbital treatment increased striatal GABA levels but did not affect theturnover rate. Barbital removal also made the rats less responsive to the effects of pentobarbital on striatal GABAlevels. These results suggest the participation of a central GABAergic system inbarbital withdrawal convulsions.
Texto completo
- http://www.sciencedirect.com/science/article/pii/0306362386901862
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Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
GABAérgicos
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
General Pharmacology Vascular System
Ano de publicação:
1986
Tipo de documento:
Article