A lipocalin sequence signature modulates cell survival
FEBS Letters
; 584(13): 2896-2900, 2010.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1062806
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Lipocalins are â-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs (motif 2) that modulates cell survival. A synthetic peptide based on an insect lipocalin displayed cytoprotective activity in serum-deprived endothelial cells and leucocytes. This activity was dependent on nitric oxide synthase. This sequence was found within several lipocalins, including apolipoprotein D, retinol binding protein, lipocalin-type prostaglandin D synthase, and many unknown proteins, suggesting that it is a sequence signature and a lipocalin conserved property.
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Sobrevivência Celular
/
Apoptose
/
Lipocalinas
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
FEBS Letters
Ano de publicação:
2010
Tipo de documento:
Article