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A new anti-loxoscelic serum produced against recombinant sphingomyelinase D Results of preclinical trials
De Almeida, D M; Fernandes-Pedrosa, M D F; Gonçalves De Andrade, R M; Marcelino, J R; Gondo Higashi, H; Junqueira De Azevedo, I D L M; Ho, P L; Van Den Berg, C; Tambourgi, D V.
Afiliação
  • De Almeida, D M; Instituto Butantan. São Paulo. BR
  • Fernandes-Pedrosa, M D F; Instituto Butantan. São Paulo. BR
  • Gonçalves De Andrade, R M; Instituto Butantan. São Paulo. BR
  • Marcelino, J R; Instituto Butantan. São Paulo. BR
  • Gondo Higashi, H; Instituto Butantan. São Paulo. BR
  • Junqueira De Azevedo, I D L M; Instituto Butantan. São Paulo. BR
  • Ho, P L; Instituto Butantan. São Paulo. BR
  • Van Den Berg, C; s.af
  • Tambourgi, D V; Instituto Butantan. São Paulo. BR
American Journal of Tropical Medicine and Hygiene ; 79(3): 463-470, Sept. 2008.
Article em En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1059622
Biblioteca responsável: BR78.1
Localização: BR78.1
ABSTRACT
Envenomation by Loxosceles species (brown spider) can lead to local dermonecrosis and to serious systemic effects. The main toxic component in the venom of these spiders is sphingomyelinase D (SMase D) and various isoforms of this toxin are present in Loxosceles venoms. We have produced a new anti-loxoscelic serum by immunizing horses with recombinant SMase D. In the present study, we compared the neutralization efficacy of the new anti-loxoscelic serum and anti-arachnidic serum (the latter serum is used for therapy for loxoscelism in Brazil) against the toxic effects of venoms from spiders of the genus Loxosceles. Neutralization tests showed that anti-SMase D serum has a higher activity against toxic effects of L. intermedia and L. laeta venoms and similar or slightly weaker activity against toxic effects of L. gaucho than that of Arachnidic serum. These results demonstrate that recombinant SMase D can replace venom for anti-venom production and therapy.
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Venenos de Aranha Limite: Animals Idioma: En Revista: American Journal of Tropical Medicine and Hygiene Ano de publicação: 2008 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Venenos de Aranha Limite: Animals Idioma: En Revista: American Journal of Tropical Medicine and Hygiene Ano de publicação: 2008 Tipo de documento: Article