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Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery
Lamy, Andre; Devereaux, Philip J; Prabhakaran, Dorairaj; Hu, Shengshou; Piegas, Leopoldo S; Straka, Zbynek; Paolasso, Ernesto; Taggart, David; Lanas, Fernando; Akar, A. Ruchan; Jain, Anil; Noiseux, Nicolas; Ou, Yongning; Chrolavicius, Susan; Ng, Jennifer; Usuf, Salim.
Afiliação
  • Lamy, Andre; Population Health Research Institute. Hamilton Health Sciences. On Behalf of the Coronary Investigators. Hamilton. CA
  • Devereaux, Philip J; Population Health Research Institute. Hamilton Health Sciences. On Behalf of the Coronary Investigators. Hamilton. CA
  • Prabhakaran, Dorairaj; National Coordination Office. Center for Chronic Disease Control and COE CARRS. On Behalf of the Coronary Investigators. New Delhi. IN
  • Hu, Shengshou; Fuwai Hospital. On Behalf of the Coronary Investigators. Beijing. CN
  • Piegas, Leopoldo S; Instituto Dante Pazzanese de Cardiologia. On Behalf of the Coronary Investigators. São Paulo. BR
  • Straka, Zbynek; Third Faculty of Medicine. Charles University. On Behalf of the Coronary Investigators. Prague. CZ
  • Paolasso, Ernesto; Instituto de Investigaciones Clínicas de Rosario (IICR). On Behalf of the Coronary Investigators. Rosario. AR
  • Taggart, David; University of Oxford. On Behalf of the Coronary Investigators. Oxford. GB
  • Lanas, Fernando; Universidad de La Frontera. On Behalf of the Coronary Investigators. Temuco. CL
  • Akar, A. Ruchan; Ankara University School of Medicine and Ankara University Stem Cell Institute. On Behalf of the Coronary Investigators. Ankara. TR
  • Jain, Anil; SAL Hospital and Medical Institute. On Behalf of the Coronary Investigators. Ahmedabad. IN
  • Noiseux, Nicolas; Centre Hospitalier Universitaire de Montreal (CHUM). On Behalf of the Coronary Investigators. Montreal. CA
  • Ou, Yongning; Population Health Research Institute. On Behalf of the Coronary Investigators. Hamilton. CA
  • Chrolavicius, Susan; Population Health Research Institute. On Behalf of the Coronary Investigators. Hamilton. CA
  • Ng, Jennifer; Population Health Research Institute. On Behalf of the Coronary Investigators. Hamilton. CA
  • Usuf, Salim; Population Health Research Institute. Hamilton Health Sciences. On Behalf of the Coronary Investigators. Hmilton. CA
Am Heart J ; 163: 1-6, 2012.
Article em En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1059423
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT
Background Uncertainty remains regarding the benefits and risks of the technique of operating on a beating heart(off pump) for coronary artery bypass grafting (CABG) surgery versus on-pump CABG. Prior trials had few events and relativelyshort follow-up. There is a need for a large randomized, controlled trial with long-term follow-up to inform both the short- andlong-term impact of the 2 approaches to CABG.Methods We plan to randomize 4,700 patients in whom CABG is planned to undergo the procedure on pump or offpump. The coprimary outcomes are a composite of total mortality, myocardial infarction (MI), stroke, and renal failure at30 days and a composite of total mortality, MI, stroke, renal failure, and repeat revascularization at 5 years. We will alsoundertake a cost-effectiveness analysis at 30 days and 5 years after CABG surgery. Other outcomes include neurocognitivedysfunction, recurrence of angina, cardiovascular mortality, blood transfusions, and quality of life.Results As of May 3, 2011, CORONARY has recruited N3,884 patients from 79 centers in 19 countries. Currently,patient's mean age is 67.6 years, 80.7% are men, 47.0% have a history of diabetes, 51.4% have a history of smoking, and34.4% had a previous MI. In addition, 20.9% of patients have a left main disease, and 96.6% have double or triplevessel disease.Conclusions CORONARY is the largest trial yet conducted comparing off-pump CABG to on-pump CABG. Its resultswill lead to a better understanding of the safety and efficacy of off-pump CABG. (Am Heart J 2012;1631-6.)
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Assunto principal: Cirurgia Torácica / Ponte de Artéria Coronária sem Circulação Extracorpórea / Infarto do Miocárdio Tipo de estudo: Clinical_trials Idioma: En Revista: Am Heart J Ano de publicação: 2012 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
Imprimir
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Assunto principal: Cirurgia Torácica / Ponte de Artéria Coronária sem Circulação Extracorpórea / Infarto do Miocárdio Tipo de estudo: Clinical_trials Idioma: En Revista: Am Heart J Ano de publicação: 2012 Tipo de documento: Article